MELATONIN REDUCES THE SEVERITY OF DEXTRAN-INDUCED COLITIS IN MICE
MELATONIN REDUCES THE SEVERITY OF DEXTRAN-INDUCED COLITIS IN MICE
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DOI：
10.1111/j.1600-079x.1995.tb00168.x
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发表时间：
1995-08-01
影响因子：
10.3
通讯作者：
BUBENIK, GA
中科院分区：
文献类型：
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作者：
PENTNEY, PT;BUBENIK, GA
褪黑素可减轻葡聚糖硫酸钠(DSS)诱导的小鼠结肠炎的严重程度，每日灌胃褪黑素(150µg/kg)7周后，所有DSS诱导结肠炎的小鼠直肠出血和隐血均消失。此外，黏膜局灶性病变的频率和严重程度也大大降低。此外，注射褪黑激素的DSS处理组小鼠的体重减轻和更高的食物消耗量被逆转，所有处理组的杯状细胞分布都由于DSS或褪黑激素的注射而发生显著变化。令人惊讶的是，接受DSS治疗的小鼠的血清褪黑素水平是对照组的10倍以上。褪黑素治疗小鼠的情况显著改善，可能是因为它对结肠的平滑肌肉、粘膜的血液供应、作为抗氧化剂和清除自由基的能力，或者对肠道免疫系统的影响。DSS处理的小鼠血浆褪黑激素水平较高可能是由于应激诱导胃肠道(GIT)褪黑激素的产生增加。
Melatonin administration reduces the severity of dextran sodium sulphate (DSS)-induced colitis in mice, After 7 weeks of daily intraperitoneal melatonin administration (150 mu g/kg), rectal bleeding and occult blood was eliminated in all mice in which colitis was induced by DSS. in addition the frequency and severity of focal lesions in the mucosa was dramatically reduced. Furthermore, weight loss and higher food consumption observed in DSS-treated mice was reversed in DSS-treated mice injected with melatonin, All treated groups exhibited significant alterations in goblet cell distribution as a result of DSS or melatonin administration. Surprisingly, serum melatonin levels were more than 10 times higher in mice that received DSS as compared to controls. The significant improvement in the conditions of melatonin-treated mice might be due to its effect on the smooth muscles of the colon, the blood supply in the mucosa, its capability as an antioxidant and scavenger of free radicals, or its effect on the immune system of the gut. The higher plasma levels of melatonin in DSS-treated mice might be due to a stress-induced increase in the production of gastrointestinal (GIT) melatonin.