Tubal ligation and risk of breast cancer.
Tubal ligation and risk of breast cancer.
复制标题
DOI：
10.1054/bjoc.1999.1182
复制
发表时间：
2000-05
影响因子：
8.8
通讯作者：
Hoover RN
中科院分区：
文献类型：
--
作者：
Brinton LA;Gammon MD;Coates RJ;Hoover RN
虽然在以前的研究中已经证明输卵管结扎术对卵巢功能有广泛的影响，包括降低随后患卵巢癌的风险，但很少有研究评估对乳腺癌风险的影响。在一项基于人群的乳腺癌病例对照研究中，20-54岁的妇女在三个地理区域进行，2173例病例中有25.3%报告既往输卵管结扎，1990例对照中有25.8%报告既往输卵管结扎。最初，输卵管结扎术似乎可以稍微降低风险，特别是在年轻时（< 25岁）接受手术的妇女中。然而，如果女性是黑人，受教育程度较低，生育第一个孩子时还年轻，或者是多胎的，那么她们更有可能接受这种手术。考虑到这些因素后，输卵管结扎与乳腺癌风险无关（相对风险（RR）= 1.09，95%置信区间（CI）0.9-1.3），风险不随年龄、手术间隔或手术日历年而变化。输卵管结扎与风险的关系并不因其他一些风险因素的存在而变化，包括绝经状态或筛查史。此外，输卵管结扎术的效果在乳腺癌诊断的所有阶段都是相似的。考虑到相关性的生物学可解释性，进一步的研究是值得的。然而，未来的研究应包括所进行手术类型的信息（因为这可能与生物学效应有关）以及其他乳腺癌风险因素。2000癌症研究运动
Although it has been demonstrated in previous studies that tubal ligation can have widespread effects on ovarian function, including a decrease in the risk of subsequent ovarian cancer, few studies have evaluated effects on breast cancer risk. In a population-based case–control study of breast cancer among women 20–54 years of age conducted in three geographic areas, previous tubal ligations were reported by 25.3% of the 2173 cases and 25.8% of the 1990 controls. Initially it appeared that tubal ligations might impart a slight reduction in risk, particularly among women undergoing the procedure at young ages (< 25 years). However, women were more likely to have had the procedure if they were black, less educated, young when they bore their first child, or multiparous. After accounting for these factors, tubal ligations were unrelated to breast cancer risk (relative risk (RR) = 1.09, 95% confidence interval (CI) 0.9–1.3), with no variation in risk by age at, interval since, or calendar year of the procedure. The relationship of tubal ligations to risk did not vary according to the presence of a number of other risk factors, including menopausal status or screening history. Furthermore, effects of tubal ligation were similar for all stages at breast cancer diagnosis. Further studies would be worthwhile given the biologic plausibility of an association. However, future investigations should include information on type of procedure performed (since this may relate to biologic effects) as well as other breast cancer risk factors. © 2000 Cancer Research Campaign