A polymorphism in the promoter region of TNF and bacterial vaginosis: Preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth
A polymorphism in the promoter region of TNF and bacterial vaginosis: Preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth
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DOI：
10.1016/j.ajog.2004.01.001
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发表时间：
2004-06-01
影响因子：
9.8
通讯作者：
Strauss, JF
中科院分区：
文献类型：
--
作者：
Macones, GA;Parry, S;Strauss, JF
目的：肿瘤坏死因子α基因（TNF）启动子多态性的2个等位基因中的罕见者与某些人群中胎膜早破后的自发性早产相关。本研究的目的是评估是否存在症状性细菌性阴道病放大自发性早产的风险在那些与“易感”TNF genotype.Study设计：病例对照研究在我们的机构进行。病例（n = 125）定义为因胎膜破裂或早产而在37周前分娩的妇女，而对照组（n = 250）定义为37周后分娩的妇女。从母体血液中收集DNA并分析TNF基因型。通过回顾产前记录获得有关有症状的细菌性阴道病和其他早产危险因素的信息。多元Logistic回归也被用来测试细菌性阴道病，TNF基因型，和早产birth.Results之间的相互作用：母亲携带者的罕见等位基因（TNF-2）是在一个显着增加自发性早产的风险[比值比（OR）2.7，95%CI 1.7-4.5]。TNF-2和早产之间的关联被细菌性阴道病的存在所改变，因此那些具有“易感”基因型和细菌性阴道病的人与那些没有的人相比，早产的几率增加。（OR 6.1，95% CI 1.9-21.0）。结论：这项研究提供了初步的证据，遗传易感性之间的相互作用（即TNF-2携带者）和环境因素（即细菌性阴道病）与自发性早产风险增加有关。(C)2004年爱思唯尔公司All rights reserved.
Objective: The rarer of 2 alleles of a polymorphism in the promoter of the tumor necrosis factor alpha gene (TNF) has been associated with spontaneous preterm birth following preterm premature rupture of the fetal membranes in some populations. The aim of this study was to assess if the presence of symptomatic bacterial vaginosis amplifies the risk of spontaneous preterm birth in those with a "susceptible" TNF genotype.Study design: A case-control study was performed at our institution. Cases (n = 125) were defined as women who delivered before 37 weeks as a result of ruptured membranes or preterm labor, while control subjects (n 250) were defined as women who delivered after 37 weeks. DNA was collected from maternal blood and analyzed for the TNF genotype. Information on symptomatic bacterial vaginosis and other risk factors for preterm birth was obtained by review of the antenatal record. Multiple logistic regression was also used to test the interaction between bacterial vaginosis, the TNF genotype, and preterm birth.Results: Maternal carriers of the rarer allele (TNF-2) were at a significantly increased risk of spontaneous preterm birth [odds ratio (OR) 2.7, 95% Cl 1.7-4.5]. The association between TNF-2 and preterm birth was modified by the presence of bacterial vaginosis, such that those with a "susceptible" genotype and bacterial vaginosis had increased odds of preterm birth compared with those who did not (OR 6.1, 95% CI 1.9-21.0).Conclusion: This study provides preliminary evidence that an interaction between genetic susceptibilities (ie, TNF-2 carriers) and environmental factors (ie, bacterial vaginosis) is associated with an increased risk of spontaneous preterm birth. (C) 2004 Elsevier Inc. All rights reserved.