Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12.
Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12.
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DOI：
10.1006/cyto.2000.0715
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发表时间：
2000-09-01
期刊：
影响因子：
3.8
通讯作者：
Barrio, E
中科院分区：
文献类型：
--
作者：
González-Quintela, A;Dominguez-Santalla, MJ;Barrio, E
细胞因子平衡的改变是酒精中毒的一些全身和肝脏表现的原因。本研究旨在评价急性戒酒和急性饮酒对血清IL-6、IL-8、IL-10和IL-12水平的影响。测定29例酒精戒断综合征患者入院时和戒酒后平均6天的血清细胞因子浓度。五名健康志愿者在基线和单次60g剂量酒精摄入36小时后进行了同样的测定。在酒精戒断综合征患者戒酒后的几天内，血清IL-6、IL-10水平升高，IL-8水平下降。健康受试者饮酒后血清IL-8水平升高。在酒精滥用者的细胞因子研究中，应考虑血清细胞因子水平随酒精摄取或戒酒的快速变化。(C)2000年学术出版社。
Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytokine concentrations were determined on admission and after a median of 6 days of ethanol abstinence in 29 patients with alcohol withdrawal syndrome. The same determinations were made in five healthy volunteers at baseline and after 36 h of a single 60 g-dose alcohol intake. Increased serum levels of IL-6, IL-10 and, to a lesser extent IL-8, declined in the few days after alcohol abstinence in patients with alcohol withdrawal syndrome. Serum IL-8 values increased after alcohol intake in healthy subjects. Rapid variation of serum cytokine levels along with alcohol intake or abstinence should be taken into account in cytokine studies in alcohol abusers. (C) 2000 Academic Press.