Efficacy of a heat exchanger mask in cold exercise-induced asthma
Efficacy of a heat exchanger mask in cold exercise-induced asthma
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DOI：
10.1378/chest.129.5.1188
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发表时间：
2006-05-01
期刊：
影响因子：
9.6
通讯作者：
Martin, Richard J.
中科院分区：
文献类型：
--
作者：
Beuther, David A.;Martin, Richard J.
研究目的：确定一种新型面罩装置在有运动性哮喘（EIA）病史的受试者中限制冷空气运动性肺功能下降的功效。环境：尽管有适当的药物治疗，许多哮喘患者在寒冷天气活动受限。设计：在研究1中，13名哮喘受试者通过安慰剂或主动热交换器面罩呼吸冷空气（-25至-15摄氏度），进行了两项随机单盲跑步机运动试验。在研究2中，5名患有EIA的受试者在呼吸冷空气的情况下进行了三次跑步机运动测试：一项测试使用热交换器面罩，一项测试不使用面罩但使用沙丁胺醇预处理，一项测试既不使用面罩也不使用沙丁胺醇预处理（无保护运动）。在所有研究中，在运动挑战前、5分钟、15分钟和30分钟进行肺活量测定。患者：在这两项研究中，共招募了15名在冷空气运动中有哮喘症状史的受试者。结果：在研究1中，安慰剂组的FEV1平均下降（+/- SE）为19 +/- 4.9%，而主动装置组的FEV1平均下降（+/- SE）为4.3 +/- 1.6% （p = 0.0002）。最大呼气中流量（FEF25-75）平均降低安慰剂组为31 +/- 5.7%，主动装置组为4.7 +/- 1.7% （p = 0.0002）。在研究2中，热交换器面罩、沙丁胺醇预处理和无保护运动的平均FEV1下降分别为6.3 +/- 3.9%、11 +/- 3.7%和28 +/- 10%（面罩与沙丁胺醇相比p = 0.4375，面罩与无保护运动相比p = 0.0625）。FEF25-75的平均下降分别为10 +/- 4.8%,23 +/- 6.0%和36 +/- 11%（口罩vs沙丁胺醇p = 0.0625，口罩vs无保护运动p = 0.0625）。结论：该热交换器面罩对冷运动引起的肺功能下降的抑制作用至少与沙丁胺醇预处理一样有效。
Study objectives: To determine the efficacy of a novel mask device in limiting cold air exercise-induced decline in lung function in subjects with a history of exercise-induced asthma (EIA).Setting: In spite of appropriate medical therapy, many asthma patients are limited in cold weather activities.Design: In study 1, 13 asthmatic subjects performed two randomized, single-blind treadmill exercise tests while breathing cold air (-25 to -15 degrees C) through a placebo or active heat exchanger mask. In study 2, five subjects with EIA performed three treadmill exercise tests while breathing cold air: one test using the heat exchanger mask, one test without the mask but with albuterol pretreatment, and one test with neither the mask nor albuterol pretreatment (unprotected exercise). For all studies, spirometry was performed before and at 5, 15, and 30 min after exercise challenge.Patients: For both studies, a total of 15 subjects with a history of asthma symptoms during cold air exercise were recruited.Results: In study 1, the mean decrease (+/- SE) in FEV1 was 19 +/- 4.9% with placebo, and 4.3 +/- 1.6% with the active device (p = 0.0002). The mean decrease in maximum mid-expiratory flow (FEF25-75) was 31 +/- 5.7% with placebo and 4.7 +/- 1.7% with the active device (p = 0.0002). In study 2, the mean decrease in FEV1 was 6.3 +/- 3.9%, 11 +/- 3.7%, and 28 +/- 10% for the heat exchanger mask, albuterol pretreatment, and unprotected exercises, respectively (p = 0.4375 for mask vs albuterol, p = 0.0625 for mask vs unprotected exercise). The mean decrease in FEF25-75 was 10 +/- 4.8%, 23 +/- 6.0%, and 36 +/- 11%, respectively (p = 0.0625 for mask vs albuterol, p = 0.0625 for mask vs unprotected exercise).Conclusions: This heat exchanger mask blocks cold exercise-induced decline in lung function at least as effectively as albuterol pretreatment.