Arsenic methylation capacity is associated with breast cancer in northern Mexico
Arsenic methylation capacity is associated with breast cancer in northern Mexico
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DOI：
10.1016/j.taap.2014.07.013
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发表时间：
2014-10-01
影响因子：
3.8
通讯作者：
Cebrian, Mariano E.
中科院分区：
文献类型：
--
作者：
Lopez-Carrillo, Lizbeth;Ulises Hernandez-Ramirez, Raid;Cebrian, Mariano E.
暴露于环境污染物，饮食因素和生活方式可能解释世界各地不同的乳腺癌（BC）发病率。饮用水中的无机砷（iAs）在许多地区是一个令人关注的问题，例如墨西哥北方。一些国家的研究表明，尿中单甲基砷的比例（%MMA）与许多砷相关疾病（包括癌症）的风险增加有关。为了研究BC风险与iAs甲基化能力之间的潜在关系，在北方墨西哥进行了一项基于医院的病例对照研究（1016例病例/1028例对照）。妇女直接接受采访，了解她们的生育史。采用HPLC-ICP-MS法测定尿中砷代谢产物的分布，并通过代谢产物的百分比和指数评价甲基化能力。尿总砷（不包括砷甜菜碱）范围为0.26 - 303.29 μ g/L。大多数妇女（86%）的TAs-AsB水平低于As生物暴露指数（35 μ g/L）。MMA和/或初级甲基化指数（PMI）较高的女性BC风险增加（MMA ORQ5vs.Q1 = 2.63; 95%CI 1.89，3.66; p趋势
Exposure to environmental contaminants, dietary factors and lifestyles may explain worldwide different breast cancer (BC) incidence. Inorganic arsenic (iAs) in the drinking water is a concern in many regions, such as northern Mexico. Studies in several countries have associated the proportion of urinary monomethylarsenic (%MMA) with increased risks for many As-related diseases, including cancer. To investigate the potential relationships between the risk of BC and the capacity to methylate iAs, a hospital-based case-control study (1016 cases/1028 controls) was performed in northern Mexico. Women were directly interviewed about their reproductive histories. The profile of As metabolites in urine was determined by HPLC-ICP-MS and methylation capacity was assessed by metabolite percentages and indexes. Total urinary As, excluding arsenobetaine (TAs-AsB), ranged from 0.26 to 303.29 mu g/L. Most women (86%) had TAs-AsB levels below As biological exposure index (35 mu g/L). Women with higher %MMA and/or primary methylation index (PMI) had an increased BC risk (%MMA ORQ5vs.Q1 = 2.63; 95%CI 1.89,3.66; p for trend