Visceral Fat Accumulation and Metabolic Risk Factor Clustering in Older Adults
Visceral Fat Accumulation and Metabolic Risk Factor Clustering in Older Adults
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DOI：
10.1111/j.1532-5415.2010.03018.x
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发表时间：
2010-09-01
影响因子：
6.3
通讯作者：
Ouchi, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Nomura, Kazushi;Eto, Masato;Ouchi, Yasuyoshi
[目的]探讨老年人CT扫描评估的内脏脂肪面积(VFA)与代谢危险因素数量之间的关系。设计横断面研究日本东京社区诊所对118名65岁及以上无日常生活活动障碍的老年人进行老年健康检查(男性63名，平均年龄74.5+/-7.1；女性155名，平均年龄75.3+/-6.7)。根据国际糖尿病联合会的标准测量除腰围以外的代谢综合征成分。结果男女VFA与代谢危险因素的数量呈正相关。多元回归分析显示，男性仅VFA与危险因素数显著相关，而女性年龄和VFA显著相关；体重指数与男性或女性代谢危险因素数无相关性。血脂异常和高血糖与高VFA相关，而高血压与高VFA无关。VFA与血清脂联素水平呈负相关，与胰岛素抵抗的稳态模型评估呈正相关。结论即使在老年人群中，内脏脂肪堆积也与代谢危险因素聚集有关。这些结果对老年人肥胖的管理具有临床意义。
OBJECTIVESTo examine the relationship between visceral fat area (VFA) evaluated using computed tomography (CT) scans and the number of metabolic risk factors in older adults.DESIGNCross-sectional studySETTINGA community clinic in Tokyo, Japan.PARTICIPANTSTwo hundred eighteen individuals aged 65 and older without impairments in activities of daily living who underwent geriatric health examination (63 men, mean age 74.5 +/- 7.1; 155 women, mean age 75.3 +/- 6.7).MEASUREMENTSVFA was obtained from a cross-sectional image at umbilical level in the supine position using CT scanning. Metabolic syndrome components except waist circumference were measured using the criteria of the International Diabetes Federation.RESULTSThere was a positive correlation between VFA and number of metabolic risk factors in men and women. Multiple regression analysis demonstrated that only VFA was significantly correlated with number of risk factors in men, whereas age and VFA were significantly correlated in women; body mass index was not correlated with number of metabolic risk factors in men or women. Dyslipidemia and high blood glucose were associated with higher VFA, but high blood pressure was not. There was a negative correlation between VFA and serum adiponectin level and a positive correlation between VFA and homeostasis model assessment of insulin resistance.CONCLUSIONVisceral fat accumulation is associated with metabolic risk factor clustering even in the elderly population. These results have clinical implications for the management of obesity in older adults.