Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.
Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.
复制标题
尿素循环障碍肝移植受者的神经系统结果可以通过移植前神经成像来预测。
DOI：
10.1111/petr.12520
复制
发表时间：
2015
影响因子：
1.3
通讯作者：
Kohli,Rohit
中科院分区：
文献类型：
--
作者：
Bolton,ScottM;Campbell,KathleenM;Kukreja,Marcia;Kohli,Rohit
Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict developmental outcomes post‐liver‐transplant in children with UCDs. Methods: Patients undergoing liver transplantation for UCDs at Cincinnati Children's Hospital Medical Center between 2002 and 2012 were identified. Neurologic assessments prior to and after transplantation were categorized into mild, moderate, or severe disability. Neuroimaging data were categorized into mild, moderate, or severe by a single pediatric neuroradiologist. Results: Fifteen patients were identified of whom eight had neuroimaging prior to transplantation. Of the eight patients that had neuroimaging, four were categorized as severe, one moderate, and three no‐to‐mild delay. All four patients whose imaging was severe were found to have moderate‐to‐severe neurologic delay. Of the three patients with no‐to‐mild changes on neuroimaging two of three were found to have no‐to‐mild delay on developmental assessments after transplantation. Conclusion: Neuroimaging may be a helpful tool in determining developmental prognosis and outcomes post‐liver‐transplantation for UCDs. Further studies maybe needed to validate our preliminary findings.
