Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
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DOI：
10.1163/156856299x00423
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发表时间：
1999-01-01
影响因子：
3.6
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Peter, SJ;Suggs, LJ;Mikos, AG
为了合成高分子量聚富马酸丙二醇酯（PPF），富马酰氯和丙二醇在碳酸钾作为质子捕获剂的存在下反应。所得低分子量低聚物的酯交换导致聚合物具有比来自先前反应方法的聚合物更大的分子量，而不需要使用催化剂。根据二维NMR，该聚合物的主链结构如预期的那样，并且不包含通过跨富马酸酯双键的酸催化加成形成的副产物。酯交换反应的动力学研究表明，在16小时后，分子量达到4900（+/-700）的最终M-n和9100（+/-1300）的M-w，而多分散指数在整个反应中保持低于1.8。因此，通过新方法合成的PPF比我们以前制备的材料具有更高的分子量和更高的纯度。
To synthesize high molecular weight poly(propylene fumarate) (PPF), fumaryl chloride and propylene glycol were reacted in the presence of potassium carbonate, which serves as a proton scavenger. Transesterification of the resulting low molecular weight oligomer led to a polymer with greater molecular weight than those from previous reaction methods without requiring the use of a catalyst. According to two-dimensional NMR, the backbone structure of this polymer was as expected and contained no byproducts formed by acid catalyzed addition across the fumarate double bond. Kinetic studies of the transesterification showed that the molecular weight reached a final M-n of 4900 (+/-700) and M-w of 9100 (+/-1300) after 16 h, while the polydispersity index remained below 1.8 throughout the reaction. Thus the PPF synthesized by the new method is of higher molecular weight and greater purity than our previously prepared material.