The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease.
The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease.
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DOI：
10.1007/s00240-013-0566-7
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发表时间：
2013-06
期刊：
影响因子：
3.1
通讯作者：
Holmes, Ross P.
中科院分区：
文献类型：
--
作者：
Knight, John;Deora, Rajendar;Assimos, Dean G.;Holmes, Ross P.
formigenes草酸杆菌是一种独特的肠道生物，依靠草酸降解来满足其大部分的能量和碳需求。缺乏定植是草酸钙结石病的一个危险因素。对草酸钙结石疾病的保护似乎是由于低钙饮食中肠道发生的草酸降解，肠道草酸分泌可能进一步起作用。生物体如何建立和维持肠道定植以及它改变结石风险的确切机制仍有待了解。对O. formigenes第1群和第2群菌株的基因组测序和注释将为鉴定与定植和生存相关的基因和途径提供所需的信息工具。在这篇综述中，我们已经确定了可能涉及的基因，并在适当的情况下提出了它们在草酸钙结石疾病中的重要作用。详细说明这些基因的功能作用应该加速我们对生物体的理解，并阐明其在防止结石形成中的作用。
Oxalobacter formigenes is a unique intestinal organism that relies on oxalate degradation to meet most of its energy and carbon needs. A lack of colonization is a risk factor for calcium oxalate stone disease. Protection against calcium oxalate stone disease appears to be due to the oxalate degradation that occurs in the gut on low calcium diets with a possible further contribution from intestinal oxalate secretion. Much remains to be learned about how the organism establishes and maintains gut colonization and the precise mechanisms by which it modifies stone risk. The sequencing and annotation of the genomes of a Group 1 and a Group 2 strain of O. formigenes should provide the informatic tools required for the identification of the genes and pathways associated with colonization and survival. In this review we have identified genes that may be involved and where appropriate suggested how they may be important in calcium oxalate stone disease. Elaborating the functional roles of these genes should accelerate our understanding of the organism and clarify its role in preventing stone formation.
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DOI：
10.1152/ajpgi.00434.2010
发表时间：
2011-03-01
影响因子：
4.5
作者：
Hatch, Marguerite;Gjymishka, Altin;Freel, Robert W.
通讯作者：
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影响因子：
3.2
作者：
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影响因子：
3.2
作者：
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影响因子：
3.2
作者：
DITTO, MD;ROBERTS, D;WEISBERG, RA
通讯作者：
WEISBERG, RA
影响因子：
5.1
作者：
Connon, SA;Tovanabootr, A;Semprini, L
通讯作者：
Semprini, L