Long-term Results of Deep Anterior Lamellar versus Penetrating Keratoplasty
Long-term Results of Deep Anterior Lamellar versus Penetrating Keratoplasty
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DOI：
10.1016/j.ophtha.2011.07.057
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发表时间：
2012-02-01
期刊：
影响因子：
13.7
通讯作者：
Laroche, Laurent
中科院分区：
文献类型：
--
作者：
Borderie, Vincent M.;Sandali, Otman;Laroche, Laurent
目的：比较深前板层角膜移植术（DALK）与穿透性角膜移植术（PK）在不累及角膜内皮的角膜疾病患眼中的疗效设计：回顾性比较病例系列。参与者：142例连续DALK患者，（DALK组;大泡技术或使用裂隙灯进行手动板层剥离）和142例匹配的PK（PK组）。联合回归模型用于预测移植物的长期存活。结果：DALK组术后5年平均内皮细胞丢失率为-22.3%，PK组为-50.1%（P < 0.05），术后5年平均内皮细胞丢失率为-22.3%（P < 0.05），PK组为-50.1%（P < 0.05），术后5年平均内皮细胞丢失率为-22.3%（P < 0.05），术后5年平均内皮细胞丢失率为-50.1%（P < 0.05），术后5年平均内皮细胞丢失率为-50.1%（P < 0.05）。
Objective: To compare deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in eyes with corneal diseases not involving the corneal endothelium (keratoconus, scars after infectious keratitis, stromal dystrophies, and trauma).Design: Retrospective, comparative case series.Participants: One hundred forty-two consecutive DALK (DALK group; big-bubble technique or manual lamellar dissection using a slitlamp) and 142 matched PK (PK group).Methods: Three models were used to describe the postoperative outcomes of the endothelial cell density. A joint regression model was used to predict long-term graft survival. Visual acuity, ultrasound pachymetry, specular microscopy, and optical coherence tomography (OCT) findings were recorded.Main Outcome Measures: Postoperative endothelial cell loss and long-term predicted graft survival.Results: The average 5-year postoperative endothelial cell loss was -22.3% in the DALK group and -50.1% in the PK group (P