Folic acid-conjugated hollow mesoporous silica/CuS nanocomposites as a difunctional nanoplatform for targeted chemo-photothermal therapy of cancer cells
Folic acid-conjugated hollow mesoporous silica/CuS nanocomposites as a difunctional nanoplatform for targeted chemo-photothermal therapy of cancer cells
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叶酸共轭中空介孔二氧化硅/CuS纳米复合材料作为双功能纳米平台用于癌细胞的靶向化学光热治疗
DOI：
10.1039/c4tb00919c
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发表时间：
2014-01-01
影响因子：
7
通讯作者：
Hu, Junqing
中科院分区：
文献类型：
--
作者：
Liu, Xijian;Fu, Fanfan;Hu, Junqing
在这项工作中，我们开发了一种新的双功能纳米平台，用于靶向化学光热治疗。它是基于中空介孔二氧化硅纳米球作为抗癌药物载体，将抗癌药物cu纳米颗粒作为光热剂附着在二氧化硅纳米球表面，叶酸（FA）与二氧化硅纳米球结合作为癌细胞靶点。该纳米平台具有良好的光热效应和优异的阿霉素（DOX）负载能力（高达49.3 wt%）。光热剂和DOX可以通过受体介导的内吞作用途径靶向递送到癌细胞中。此外，pH值和近红外光可以触发中空介孔二氧化硅纳米球中DOX的释放。980 nm激光照射可同时驱动化疗和光热治疗。更重要的是，化疗与光热联合治疗比单独治疗效果更好，显示出协同作用。
In this work, we have developed a novel difunctional nanoplatform for targeted chemo-photothermal therapy. It is based on hollow mesoporous silica nanospheres as a carrier for anticancer drug-loading CuS nanoparticles attached on a silica nanosphere surface as a photothermal agent, and folic acid (FA) conjugated with a silica nanosphere as a cancer cell target. The nanoplatform has demonstrated a good photothermal effect and excellent doxorubicin (DOX) loading capacity (as high as 49.3 wt%). The photothermal agent and DOX can be targeted to deliver into cancer cells via a receptor mediated endocytosis pathway. Moreover, the release of DOX from the hollow mesoporous silica nanospheres can be triggered by pH and NIR light. Both chemotherapy and photothermal therapy can be simultaneously driven by irradiation with a 980 nm laser. More importantly, the combination of chemotherapy and photothermal therapy shows a better therapy effect than the individual therapies, thus demonstrating a synergistic action.