Real-Time Video Imaging of Mechanical Motions of a Single Molecular Shuttle with Sub-Millisecond Sub-Angstrom Precision
Real-Time Video Imaging of Mechanical Motions of a Single Molecular Shuttle with Sub-Millisecond Sub-Angstrom Precision
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DOI：
10.1246/bcsj.20200134
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发表时间：
2020-09-01
影响因子：
4
通讯作者：
Nakamura, Eiichi
中科院分区：
文献类型：
--
作者：
Shimizu, Toshiki;Lungerich, Dominik;Nakamura, Eiichi
小型化的机器开辟了化学的一个新维度，通常是对众多分子的平均研究，或者对结合在坚固底物上的单个分子的研究。然而，单个分子水平上的机械运动是在量子控制下进行的，与其环境的波动强烈耦合--这个系统很少被研究，因为缺乏一种实时观察纳米机械运动的有效方法。在这里，我们报告了使用电子显微镜、快速相机和去噪算法，以0.625毫秒(Ms)/帧或1600fps的速度，对单个富勒烯分子以0.625毫秒(Ms)/帧或1600fps的速度穿梭、旋转和与振动的碳纳米管相互作用的精确原位视频成像。我们实现了分子机械运动与碳纳米管振动耦合的原位观测，其标准误差在时间上为0.9毫秒，在空间上为0.01 nm。我们揭示了丰富的分子动力学，其中运动是非线性的、随机的，通常是不可重复的，以及分子水平上的功和能量关系，以前通过时间平均测量或显微镜无法检测到。在1600-fps速率下的分子视频记录超过了以前连续记录分子运动的100倍。
Miniaturized machines have open up a new dimension of chemistry, studied usually as an average over numerous molecules or for a single molecule bound on a robust substrate. Mechanical motions at a single molecule level, however, are under quantum control, strongly coupled with fluctuations of its environment-a system rarely addressed because an efficient way of observing the nanomechanical motions in real time is lacking. Here, we report sub-millisecond sub-A precision in situ video imaging of a single fullerene molecule shuttling, rotating, and interacting with a vibrating carbon nanotube at 0.625 milliseconds(ms)/frame or 1600 fps, using an electron microscope, a fast camera, and a denoising algorithm. We have achieved in situ observation of the mechanical motions of a molecule coupled with vibration of a carbon nanotube with standard error as small as 0.9 millisecond in time and 0.01 nm in space. We have revealed rich molecular dynamics, where motions are non-linear, stochastic and often non-repeatable, and a work and energy relationship at a molecular level previously undetected by time-averaged measurements or microscopy. The molecular video recording at a 1600-fps rate exceeds by 100 times the previous records of continuous recording of molecular motions.