Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III. Pulmonary function, electromyograms, limb tremor, and tissue manganese data.
Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III. Pulmonary function, electromyograms, limb tremor, and tissue manganese data.
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DOI：
10.1080/15298667991429688
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发表时间：
1979-05
期刊：
影响因子：
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通讯作者：
Charles E. Ulrich;William E. Rinehart;Manual Brandt
中科院分区：
文献类型：
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作者：
Charles E. Ulrich;William E. Rinehart;Manual Brandt
猴子和大鼠每天24小时暴露于11.6微克、112.5微克和1152微克锰/立方米的Mn3O4气雾剂中，持续9个月。对肺功能、肌电活动、肢体震颤和组织锰水平进行了各种评估。未观察到暴露对肺功能、肢体震颤或肌电活动的相关影响。暴露9个月后，肾、肺、脾和血液中的锰水平以接近剂量相关的方式升高。然而，暴露6个月后，与对照组相比，组织中的锰水平没有差异，这可能是由于暴露条件的原因。
Monkeys and rats were exposed to 11.6, 112.5, and 1152 micrograms Mn/m3 as an Mn3O4 aerosol twenty-four hours per day for nine months. Various evaluations of pulmonary function, electromyographic activity, limb tremor, and tissue manganese levels were conducted. No exposure related effects on pulmonary function, limb tremor, or electromyographic activity were observed. After nine months of exposure Mn levels were elevated in a near dose related manner in kidney, lung, spleen, and blood. However, by six months postexposure there were no differences as compared to the control group in tissue Mn levels which could be attributed to the exposure conditions.