Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion
Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion
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DOI：
10.1016/j.nut.2012.08.004
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发表时间：
2013-01-01
期刊：
影响因子：
4.4
通讯作者：
Dugo, Paola
中科院分区：
文献类型：
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作者：
Mandalari, Giuseppina;Bisignano, Carlo;Dugo, Paola
目的：从开心果中提取的生物活性物质的生物可达性尚未被评估过。在本研究中，我们量化了开心果(生开心果、腌制开心果和生开心果松饼)在模拟人类消化过程中多酚、叶黄素和生育酚的释放。方法：采用胃动态消化模型，提供了真实和预测的物理和化学过程模拟，并准确地模拟了人体胃内的停留时间和腔环境。结果：超过90%的多酚物质在胃中释放，几乎全部释放在十二指肠相中。生去壳的开心果和腌制的开心果之间没有显著差异。食物基质(松饼)的存在降低了原儿茶酸(78%)和木犀草素(36%)的生物可及性。经十二指肠消化后，叶黄素和生育酚的生物可及性几乎为100%，三种样品之间没有差异。结论：被测生物活性物质在胃中的快速释放最大限度地提高了十二指肠的吸收潜力，有助于建立开心果消费与健康相关结果之间的有益关系。(C)2013 Elsevier Inc.保留所有权利。
Objective: The bioaccessibility of bioactives from pistachios has not been previously evaluated. In the present study we quantified the release of polyphenols, xanthophylls (lutein), and tocopherols from pistachios (raw pistachios, roasted salted pistachios, and muffins made with raw pistachios) during simulated human digestion.Methods: A dynamic gastric model of digestion that provides a realistic and predictive simulation of the physical and chemical processing and accurately mimics the residence time and the luminal environment within the human stomach was used for the digestion studies.Results: More than 90% of the polyphenols were released in the gastric compartment, with virtually total release in the duodenal phase. No significant differences were observed between raw shelled and roasted salted pistachio. The presence of a food matrix (muffin) decreased the bioaccessibility of protocatechuic acid (78%) and luteolin (36%). Almost 100% bioaccessibility of lutein and tocopherols was found after duodenal digestion, with no difference among the three samples.Conclusion: The rapid release of the assayed bioactives in the stomach maximizes the potential for absorption in the duodenum and contributes to the beneficial relation between pistachio consumption and health-related outcomes. (C) 2013 Elsevier Inc. All rights reserved.