No evidence of associations among body composition and symptoms in persons with multiple sclerosis.
No evidence of associations among body composition and symptoms in persons with multiple sclerosis.
复制标题
没有证据表明多发性硬化症患者的身体成分和症状之间存在关联。
DOI：
10.1037/rep0000292
复制
发表时间：
2020
影响因子：
2.7
通讯作者：
R. Motl
中科院分区：
文献类型：
--
作者：
S. Silveira;L. Pilutti;R. Motl
目的
研究人体组成（定义为体脂量（BF）和瘦体重（LM）的百分比）、骨矿物质含量（BMC）和骨矿物质密度（BMD）与症状（即，疲劳、疼痛、抑郁、焦虑和睡眠质量差）。
设计
本研究是对来自MS患者的身体活动干预的基线数据的二次分析。研究问题由不愉快症状的理论提供信息，即检查身体成分（即，生理前因）和症状之间的联系进行了检查，使用偏相关分析控制年龄，性别和残疾状态。
结果
参与者平均年龄为49 ± 9岁，平均诊断为MS 12 ± 8年。大多数参与者被确定为女性（74%），报告有复发缓解型疾病病程（78%），根据中位数（四分位数间距）患者确定的疾病步骤评分为3.0（3.0），中度MS相关残疾。偏相关分析表明，身体成分（%BF，%LM，BMC和BMD）和任何症状（疲劳，疼痛，抑郁，焦虑和睡眠质量）之间没有显着的相关性。
结论
其他的研究，检查其他生理因素以及心理和情境因素的基础上，不愉快的症状，可能占MS患者的症状的理论是必要的。这将为行为干预和康复计划提供信息，这些计划针对基于理论的因素，例如MS中的症状相关性（PsycINFO数据库记录（c）2019阿帕，保留所有权利）。
OBJECTIVE
To examine the association among body composition, defined as the percentage of body fat mass (BF) and lean mass (LM), bone mineral content (BMC) and bone mineral density (BMD) in the human body and the presentation of symptoms (i.e., fatigue, pain, depression, anxiety, and poor sleep quality) in persons with multiple sclerosis (MS).
DESIGN
The present study is a secondary analysis of baseline data from a physical activity intervention for persons with MS. The research question was informed by the theory of unpleasant symptoms, namely an examination of the relationship between body composition (i.e., physiologic antecedent) and symptoms in this sample of 77 participants with MS. The association between body composition and symptoms was examined using partial correlation analyses controlling for age, sex, and disability status.
RESULTS
Participants were 49 ± 9 years of age on average and diagnosed with MS for an average of 12 ± 8 years. Most participants identified as female (74%), reported having a relapsing-remitting disease course (78%), and moderate MS-related disability based on a median (interquartile range) Patient Determined Disease Steps score of 3.0 (3.0). Partial correlation analyses indicate there were no significant correlations observed among body composition (%BF, %LM, BMC, and BMD) and any symptoms (fatigue, pain, depression, anxiety, and sleep quality).
CONCLUSION
Additional research that examines other physiologic factors as well as psychological and situational factors based on the theory of unpleasant symptoms that might account for symptoms in persons with MS is necessary. This will inform behavioral interventions and rehabilitation programs that target theory-based factors such as correlates of symptoms in MS. (PsycINFO Database Record (c) 2019 APA, all rights reserved).