Short-Term Air Pollution as a Risk for Stroke Admission: A Time-Series Analysis
Short-Term Air Pollution as a Risk for Stroke Admission: A Time-Series Analysis
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DOI：
10.1159/000510080
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发表时间：
2020-09-01
影响因子：
2.9
通讯作者：
Williams, David J.
中科院分区：
文献类型：
--
作者：
Byrne, Colm Patrick;Bennett, Kathleen E.;Williams, David J.
背景：室外空气污染对脑卒中发病率的有害影响越来越被认识到。我们研究了2013年至2017年爱尔兰两个城市中心不同空气污染物（PM2.5，PM10，NO2，臭氧和SO2）对所有中风入院的影响。方法：使用泊松回归模型的生态时间序列设计，我们分析了都柏林或科克居住的所有中风和缺血性中风的每日住院情况，空气污染水平监测数据与暴露时间的滞后为0-2天。温度、相对湿度、星期几和时间的样条作为混杂因素。还对所有四个季节进行了分析。数据呈现为相对危险度（RRs）和95%置信区间（95%CI）每四分位数范围（IQR）增加在each pollutant.Results：有所有中风入院和任何个别空气污染物之间没有显着关联。在季节性分析中，在较大的城市中心（都柏林）的冬季，我们发现所有中风病例与NO2的IQR增加之间存在关联（RR 1.035，95% CI：1.003-1.069）、PM10（RR 1.032，95% CI：1.007-1.057）、PM2.5（RR 1.024，95% CI：1.011-1.039）和SO2（RR 1.035，95% CI：1.001-1.071）。在科克较小的城市地区没有发现明显的关联。在荟萃分析中，仍然有一个显着的关联NO2（RR 1.013，95%CI：1.001-1.024）和PM2.5（1.009，95%CI 1.004-1.014）每IQR increases.Discussion：短期空气污染在冬季被发现与住院治疗的所有中风在爱尔兰的一个大城市中心。由于爱尔兰的空气污染在国际上相对较低，这突出表明需要引入政策变革，以减少所有国家的空气污染。
Background:The harmful effects of outdoor air pollution on stroke incidence are becoming increasingly recognised. We examined the impact of different air pollutants (PM2.5, PM10, NO2, ozone, and SO2) on admission for all strokes in two Irish urban centres from 2013 to 2017.Methods:Using an ecological time series design with Poisson regression models, we analysed daily hospitalisation for all strokes and is-chaemic stroke by residence in Dublin or Cork, with air pollution level monitoring data with a lag of 0-2 days from exposure. Splines of temperature, relative humidity, day of the week, and time were included as confounders. Analysis was also performed across all four seasons. Data are presented as relative risks (RRs) and 95% confidence intervals (95% CI) per interquartile range (IQR) increase in each pollutant.Results:There was no significant association between all stroke admission and any individual air pollutant. On seasonal analysis, during winter in the larger urban centre (Dublin), we found an association between all stroke cases and an IQR increase in NO2 (RR 1.035, 95% CI: 1.003-1.069), PM10 (RR 1.032, 95% CI: 1.007-1.057), PM2.5 (RR 1.024, 95% CI: 1.011-1.039), and SO2 (RR 1.035, 95% CI: 1.001-1.071). There was no significant association found in the smaller urban area of Cork. On meta-analysis, there remained a significant association between NO2 (RR 1.013, 95% CI: 1.001-1.024) and PM2.5 (1.009, 95% CI 1.004-1.014) per IQR increase in each.Discussion:Short-term air pollution in winter was found to be associated with hospitalisation for all strokes in a large urban centre in Ireland. As Ireland has relatively low air pollution internationally, this highlights the need to introduce policy changes to reduce air pollution in all countries.