SARCOMA INDUCTION IN MICE BY METHYLCHOLANTHRENE - ANTIGENICITY TESTS OF SARCOMAS INDUCED IN THYMUS GRAFTED AND CONTROL ANIMALS
SARCOMA INDUCTION IN MICE BY METHYLCHOLANTHRENE - ANTIGENICITY TESTS OF SARCOMAS INDUCED IN THYMUS GRAFTED AND CONTROL ANIMALS
复制标题
DOI：
10.1038/bjc.1969.50
复制
发表时间：
1969-01-01
影响因子：
8.8
通讯作者：
MARCHANT, J
中科院分区：
文献类型：
--
作者：
MARCHANT, J
材料与方法雄性和雌性F1(C57BLx IF)小鼠皮下注射1 mg。3个月大时，在右侧橄榄油中加入3-甲基胆蒽(MC)。一半的动物在注射MC前5周开始，每两周接受一次整个胸腺的皮下移植。移植物来自出生6至10天的同性同基因供者。24只动物中有22只出现肉瘤。
MATERIALS AND METHODSTunmoars Male and female F1 (C57BL x IF) mice were given a subcutaneous injection of 1 mg. of 3-methylcholanthrene (MC) in olive oil on the right flank when 3 months old. Half of the animals also received a subcutaneous graft of a whole thymus gland once a fortnight, beginning 5 weeks before the MC injection. The grafts came from 6-to 10-day-old syngeneic donors of the same sex. Sarcomas arose in 22 of 24 animals.