Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches.
Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches.
复制标题
DOI：
10.3390/ijms18050960
复制
发表时间：
2017-05-03
影响因子：
5.6
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Ali L;Goraya MU;Arafat Y;Ajmal M;Chen JL;Yu D
群体感应系统控制粪肠球菌的主要毒力决定因素，粪肠球菌可引起医院感染。粪肠球菌群体感应系统包括几种由编码溶细胞素毒素的溶细胞素操纵子调节的毒力因子。此外，粪肠球菌 Fsr 调节系统控制明胶酶、丝氨酸蛋白酶和肠菌素 O16 的表达。溶细胞素和 Fsr 毒力因子系统与影响人类和其他宿主模型健康的肠球菌疾病有关。因此，人们对了解和靶向这些调控途径以开发控制肠球菌感染的新疗法非常感兴趣。群体感应抑制剂可能是减轻粪肠球菌致病作用的潜在治疗剂。在这里，我们讨论溶细胞素、LuxS 系统和 Fsr 系统的调节、它们在粪肠球菌介导的感染中的作用，以及预防粪肠球菌感染的可能治疗方法。
Quorum-sensing systems control major virulence determinants in Enterococcus faecalis, which causes nosocomial infections. The E. faecalis quorum-sensing systems include several virulence factors that are regulated by the cytolysin operon, which encodes the cytolysin toxin. In addition, the E. faecalis Fsr regulator system controls the expression of gelatinase, serine protease, and enterocin O16. The cytolysin and Fsr virulence factor systems are linked to enterococcal diseases that affect the health of humans and other host models. Therefore, there is substantial interest in understanding and targeting these regulatory pathways to develop novel therapies for enterococcal infection control. Quorum-sensing inhibitors could be potential therapeutic agents for attenuating the pathogenic effects of E. faecalis. Here, we discuss the regulation of cytolysin, the LuxS system, and the Fsr system, their role in E. faecalis-mediated infections, and possible therapeutic approaches to prevent E. faecalis infection.