Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa.
Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa.
复制标题
DOI：
10.1021/acs.orglett.6b00979
复制
发表时间：
2016-06-03
期刊：
影响因子：
5.2
通讯作者：
Baker BJ
中科院分区：
文献类型：
--
作者：
von Salm JL;Witowski CG;Fleeman RM;McClintock JB;Amsler CD;Shaw LN;Baker BJ
从南极Dendrilla membranosa海绵中分离到一种新的重排海绵二萜--达尔文双萜。根据光谱和晶体学分析的特征，假设中心七元环起源于海绵前体的环扩张。与耐甲氧西林金黄色葡萄球菌的生物膜相相比，达尔文耐药蛋白显示出4倍的选择性，并且可以为开发这种难以治疗的感染的治疗剂提供支架。
A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of spectroscopic and crystallographic analysis, the central seven-membered ring is hypothesized to originate from a ring-expansion of a spongian precursor. Darwinolide displays 4-fold selectivity against the biofilm phase of methicillin-resistant Staphylococcus aureus compared to the planktonic phase and may provide a scaffold for the development of therapeutics for this difficult to treat infection.