Incidence of Cutaneous Lupus Erythematosus, 1965-2005 A Population-Based Study
Incidence of Cutaneous Lupus Erythematosus, 1965-2005 A Population-Based Study
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DOI：
10.1001/archdermatol.2009.21
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发表时间：
2009-03-01
影响因子：
--
通讯作者：
Rohlinger, Audrey L.
中科院分区：
文献类型：
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作者：
Durosaro, Olayemi;Davis, Mark D. P.;Rohlinger, Audrey L.
目的：评估红斑狼疮（CLE）皮肤变异的趋势，并确定过去40年CLE的发病率。设计：回顾性人群研究。设置：社区流行病学项目。患者：明尼苏达州奥姆斯特德县所有1965年1月至2005年12月期间患有任何亚型CLE的居民。主要结果测量：CLE的发病率和疾病进展为系统性LE（SLE）。结果：在1965年至2005年期间，共确定了156例新诊断的CLE患者（100例女性和56例男性）。发生率（根据2000年美国白色人群调整的年龄和性别）为4.30/100 000（95%置信区间[CI]，3.62-4.98）。截至2006年1月1日，经年龄和性别调整的患病率为73.24/100 000（95% CI，58.29-88.19）。19例CLE患者疾病进展为SLE：20年时的累积发生率为19%;平均（SD）进展时间为8.2（6.3）年。与之前报道的2.78 1965年至1992年，明尼苏达州罗切斯特居民中SLE的发生率为每10万人（95% CI，2.08-3.49），罗切斯特的CLE发生率为3.08（95%CI，2.32-3.83）/10万。结论：CLE的发病率与已发表的SLE发病率相当。我们的研究结果使被称为LE（SLE和CLE）的疾病过程的根源名称的发生率增加了一倍。
Objectives: To assess trends in the cutaneous variants of lupus erythematosus (CLE) and to ascertain the incidence of CLE over the past 4 decades.Design: Retrospective population-based study.Setting: Community-based epidemiology project.Patients: All Olmsted County, Minnesota, residents with any subtype of CLE between January 1965 and December 2005.Main Outcome Measures: Incidence of CLE and disease progression to systemic LE (SLE).Results: A total of 156 patients with newly diagnosed CLE (100 females and 56 males) were identified between 1965 and 2005. The incidence rate (age and sex adjusted to the 2000 US white population) was 4.30 (95% confidence interval [CI], 3.62-4.98) per 100 000. The age-and sex-adjusted prevalence as of January 1, 2006, was 73.24 (95% CI, 58.29-88.19) per 100 000. Nineteen patients with CLE had disease progression to SLE: cumulative incidence at 20 years, 19%; mean (SD) length to progression, 8.2 (6.3) years. Compared with a previously reported incidence of 2.78 (95% CI, 2.08-3.49) per 100 000 for SLE among Rochester, Minnesota, residents in 1965 through 1992, the incidence of CLE in Rochester was 3.08 (95% CI, 2.32-3.83) per 100 000 in 1965 through 1992.Conclusions: The incidence of CLE is comparable to the published incidence of SLE. Our findings double the incidence of the root designation of the disease process known as LE (SLE and CLE).