Retinal thickness in diabetic retinopathy - A study using optical coherence tomography (OCT)
Retinal thickness in diabetic retinopathy - A study using optical coherence tomography (OCT)
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DOI：
10.1097/00006982-200212000-00012
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发表时间：
2002-12-01
影响因子：
3.3
通讯作者：
Kretzchmar-Gross, T
中科院分区：
文献类型：
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作者：
Goebel, W;Kretzchmar-Gross, T
背景和目的：作者进行了一项对照研究，使用光学相干断层扫描（OCT）作为客观和非侵入性的工具来量化糖尿病视网膜病变的黄斑视网膜厚度。方法：对136例不同阶段的糖尿病视网膜病变患者进行OCT检查，同时进行荧光素血管造影和标准眼科检查。对照组由30个人与正常macula.Results：在控制，视网膜厚度为153 +/- 15妈妈在中央凹，249 +/- 19妈妈在颞叶旁区域，和268 +/- 20妈妈在鼻叶旁区域。在糖尿病患者中，视网膜厚度在中央凹中增加到307 +/- 136 μ m，在颞侧视网膜中增加到337 +/- 88 μ m，在鼻侧视网膜中增加到353 +/- 95 μ m。糖尿病组与对照组比较，差异有非常显著性意义（P < 0.001）。视网膜增厚与眼底荧光素渗漏有一定相关性。视网膜厚度和视力之间存在中等相关性，特别是在没有黄斑缺血的患者中。结论：光学相干断层扫描技术可用于糖尿病视网膜病变视网膜厚度的定量分析，具有良好的重复性。OCT能够以很高的可靠性检测威胁视力的黄斑水肿。
Background and Objective: The authors conducted a controlled study to quantify macular retinal thickness in diabetic retinopathy using optical coherence tomography (OCT) as an objective and noninvasive tool. The relationship between retinal thickness and standard methods of evaluating macular edema was investigated.Patients and Methods: A total of 136 patients in different stages of diabetic retinopathy were examined with OCT. In addition, fluorescein angiograms as well as standard eye examinations were conducted. The control group consisted of 30 individuals with a normal macula.Results: In the controls, retinal thickness was 153 +/- 15 mum in the fovea, 249 +/- 19 mum in the temporal parafoveal region, and 268 +/- 20 mum in the nasal parafoveal region. In diabetic patients, retinal thickness was increased to 307 +/- 136 mum in the fovea, 337 +/- 88 Am in the temporal retina, and 353 +/- 95 mum in the nasal retina, respectively. The differences between diabetics and controls were highly significant (P < 0.001). Retinal thickening correlated with fluorescein leakage in the angiograms to some extent. There was an intermediate correlation between retinal thickness and visual acuity, particularly in patients without macular ischemia. Sensitivity of detecting clinically significant macular edema by measuring foveal retinal thickness was 89% and specificity was 96%.Conclusion: Optical coherence tomography allows us to quantify retinal thickness in diabetic retinopathy with excellent reproducibility. OCT is able to detect sight-threatening macular edema with great reliability.