Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs.
Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs.
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DOI：
10.1186/1471-2288-10-26
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发表时间：
2010-04-01
影响因子：
4
通讯作者：
Rogers KD
中科院分区：
文献类型：
--
作者：
Mealing NM;Banks E;Jorm LR;Steel DG;Clements MS;Rogers KD
关于应答率相对较低或代表性有限的研究的相对风险估计的普遍性，几乎没有经验证据。本研究的目的是通过比较45岁及以上研究、一项基于人群的队列研究（自填式邮寄问卷，应答率18%）和新南威尔士州人口健康调查（PHS）（计算机辅助电话访谈，应答率约60%）的估计值，调查同一人群不同应答率和设计的研究中的风险-结局关系的变化。对45名及以上研究参与者（n = 101，812）和2006/2007年PHS参与者（n = 14，796）的问卷数据进行逻辑回归分析，以计算可比变量的患病率估计值和比值比（OR），并对年龄，性别和偏远程度进行调整。使用Wald检验对每项研究分别建模，在有和没有采样权重的情况下比较OR。两项研究的某些结果（吸烟、私人健康保险、糖尿病、高血压、哮喘）的患病率不同。对于高度可比的问卷项目，研究之间的确定性-结果关系模式几乎相同，并且检查的10种关系中有8种的OR没有显著差异。对于只有适度可比性的问卷项目，观察到的关系的性质在两项研究之间没有实质性差异，尽管许多OR显著不同。这些研究结果表明，对于广泛的风险因素，两项研究相同的人口与不同的答复率，抽样框架和问卷管理模式产生了一致的估计的风险结果的关系。然而，研究之间的OR不同，他们没有使用相同的问卷调查项目。
There is little empirical evidence regarding the generalisability of relative risk estimates from studies which have relatively low response rates or are of limited representativeness. The aim of this study was to investigate variation in exposure-outcome relationships in studies of the same population with different response rates and designs by comparing estimates from the 45 and Up Study, a population-based cohort study (self-administered postal questionnaire, response rate 18%), and the New South Wales Population Health Survey (PHS) (computer-assisted telephone interview, response rate ~60%). Logistic regression analysis of questionnaire data from 45 and Up Study participants (n = 101,812) and 2006/2007 PHS participants (n = 14,796) was used to calculate prevalence estimates and odds ratios (ORs) for comparable variables, adjusting for age, sex and remoteness. ORs were compared using Wald tests modelling each study separately, with and without sampling weights. Prevalence of some outcomes (smoking, private health insurance, diabetes, hypertension, asthma) varied between the two studies. For highly comparable questionnaire items, exposure-outcome relationship patterns were almost identical between the studies and ORs for eight of the ten relationships examined did not differ significantly. For questionnaire items that were only moderately comparable, the nature of the observed relationships did not differ materially between the two studies, although many ORs differed significantly. These findings show that for a broad range of risk factors, two studies of the same population with varying response rate, sampling frame and mode of questionnaire administration yielded consistent estimates of exposure-outcome relationships. However, ORs varied between the studies where they did not use identical questionnaire items.
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影响因子：
4.4
作者：
Goodman, Robert;Iervolino, Alessandra C.;Maughan, Barbara
通讯作者：
Maughan, Barbara
影响因子：
7.7
作者：
Eastwood, BJ;Gregor, RD;Wolf, HK
通讯作者：
Wolf, HK
影响因子：
7.7
作者：
Lee, C;Dobson, AJ;Young, AF
通讯作者：
Young, AF
影响因子：
5.4
作者：
Nohr, EA;Frydenberg, M;Olsen, J
通讯作者：
Olsen, J
影响因子：
5
作者：
AUSTIN, MA;CRIQUI, MH;HOLDBROOK, MJ
通讯作者：
HOLDBROOK, MJ