Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy
Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy
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DOI：
10.1080/13550280290100480
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发表时间：
2002-08-01
影响因子：
3.2
通讯作者：
Karlsson, H
中科院分区：
文献类型：
--
作者：
Aronsson, F;Lannebo, C;Karlsson, H
流行病学研究表明胎儿时期甲型流感病毒感染与神经精神疾病之间存在关联。为了研究甲型流感病毒感染导致神经系统功能障碍的可能性，我们描述了一种小鼠模型，该模型使用小鼠神经适应型流感 A/WSN/33 毒株鼻内滴注到怀孕小鼠中。在胎儿大脑中检测到病毒 RNA 和核蛋白，并且病毒 RNA 在出生后至少持续 90 天。因此，我们获得了流感病毒在小鼠体内经胎盘传播以及病毒成分在这些动物的大脑中持续存在到成年早期的证据。
Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood.