Calcinosis cutis following extravasation of calcium gluconate in neonates.
Calcinosis cutis following extravasation of calcium gluconate in neonates.
复制标题
新生儿葡萄糖酸钙外渗后皮肤钙质沉着。
DOI：
10.7097/aps.199902.0034
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Sung
中科院分区：
文献类型：
--
作者：
S. Mu;C. H. Lin;T. Sung
新生儿低钙血症并不少见，尤其是早产儿。静脉滴注葡萄糖酸钙可有效治疗。自1997年1月至1997年12月，我们治疗了9名新生儿在葡萄糖酸钙替代钙后出现皮下钙沉积。其中三名婴儿是由糖尿病母亲所生，两名婴儿有围产期窒息，四名婴儿早产。平均给药次数为7.4次（5 - 9次给药）。首次给药后5 - 11天发生皮肤钙质沉着症。葡萄糖酸钙的替代品在外渗和关节活动挛缩的部位引起不定形的肿块。进行放射学研究以确定外渗的程度和过程，远离输注部位的区域也显示钙化。除了支持治疗和皮肤移植外，没有特殊的治疗方式。患者功能恢复，但有美容残留物。在我们的随访诊所中，所有婴儿都完全康复，没有功能限制。
Neonatal hypocalcemia is not an uncommon condition, especially in the premature neonate. It is effectively treated by intravenous infusion with calcium gluconate. We treated nine neonates with subcutaneous calcium deposition following calcium replacement with calcium gluconate from Jan. 1997 to Dec. 1997. Three of the infants were born to diabetic mothers, two had perinatal asphyxia and four were born prematurity. The average dosing number was 7.4 (5 to 9 doses). The onset of calcinosis cutis was 5 to 11 days after the first dose. The replacement of calcium gluconate caused amorphous masses at the site of extravasation and contracture of joint movement. A radiographic study was performed to determine the extent and course of extravasation, and areas remote from the infusion site also showed calcification. There is no specific mode of treatment except supportive management and a skin graft. The patient could functionally recover with cosmetic residue. In our follow-up clinics, all infants completely recovered without functional limitations.