INVIVO SECRETION OF 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE, A POTENT ANESTHETIC STEROID, BY THE ADRENAL-GLAND OF THE RAT
INVIVO SECRETION OF 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE, A POTENT ANESTHETIC STEROID, BY THE ADRENAL-GLAND OF THE RAT
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DOI：
10.1016/0022-4731(85)90147-5
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发表时间：
1985-01-01
影响因子：
4.1
通讯作者：
OLIVERS, JT
中科院分区：
文献类型：
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作者：
HOLZBAUER, M;BIRMINGHAM, MK;OLIVERS, JT
3.alpha.-羟基-5 αAllo-THP是一种具有强麻醉特性的类固醇，由大鼠肾上腺分泌，其分泌量与大鼠卵巢分泌的量相似。根据这种和其他内源性类固醇的催眠效力，毫无疑问，雌性大鼠体内产生的具有麻醉性质的类固醇总量足以对某些脑细胞产生催眠作用。在肾上腺完整的大鼠中，allo-THP的肾上腺分泌与孕酮和异炔诺酮之间存在正相关，而与DOC脱氧皮质酮之间存在负相关。这可能是负责孕酮的氧化和还原的酶之间竞争的结果，孕酮是allo-THP和DOC的共同前体。提示allo-THP可能具有抗肿瘤作用。
3.alpha.-Hydroxy-5.alpha.-pregnan-20 (allo-THP), a steroid with strong anesthetic properties, was secreted by the adrenal gland of the rat in quantities similar to those secreted by the rat ovary. From the hypnotic potencies established for this and other endogenous steroids there can be little doubt that the total amount of steroids with anesthetic properties produced in a female rat are sufficient to exert a depressant action on certain cells of the brain. In rats with intact adrenal glands a positive correlation existed between the adrenal secretion of allo-THP and pregnenolone or progesterone; that between allo-THP and DOC deoxycorticosterone was negative. This could be the result of a competition between the enzymes responsible for the oxidation and reduction of progesterone, the common precursor of allo-THP and DOC. The possibility that allo-THP could have hypotensive actions was suggested.