Analgesic Use and Sex Steroid Hormone Concentrations in Postmenopausal Women
Analgesic Use and Sex Steroid Hormone Concentrations in Postmenopausal Women
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DOI：
10.1158/1055-9965.epi-09-0975
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发表时间：
2010-04-01
影响因子：
3.8
通讯作者：
Hankinson, Susan E.
中科院分区：
文献类型：
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作者：
Gates, Margaret A.;Tworoger, Shelley S.;Hankinson, Susan E.
先前的流行病学研究表明，定期使用止痛药可能会降低乳腺癌和卵巢癌的风险。在护士健康研究中，我们调查了740名绝经后妇女服用阿司匹林、非阿司匹林、非类固醇抗炎药(NSAID)以及对乙酰氨基酚和性类固醇激素浓度之间的关系，从而探索了这些关联的可能的激素调节机制。所有妇女都报告在1988年或1990年使用了止痛药，并在1989年至1990年提供了血样。我们计算了每一类止痛药使用的调整几何平均雌激素和雄激素水平，并计算了随着使用频率的增加而变化的趋势的P值。1990年，每月服用阿司匹林、非阿司匹林非类固醇抗炎药或对乙酰氨基酚的天数与激素水平之间没有相关性(所有P-Trend>；=0.09)。然而，我们观察到1988年估计的每月阿司匹林片数与雌酮浓度(P趋势=0.04)和硫酸雌酮浓度(P趋势=0.03)之间存在显著的相反趋势。在1990年对(阿司匹林和非阿司匹林)非甾体类抗炎药总使用量的分析中，每月至少服用非类固醇抗炎药15天的妇女的雌二醇水平显著低于未服用非类固醇抗炎药的妇女(P-趋势=0.03)。1990年所有止痛药(阿司匹林、非阿司匹林、非阿司匹林和对乙酰氨基酚)的使用频率与雌二醇(P趋势=0.001.0 1)、游离雌二醇(P趋势=0.0 1)、硫酸雌酮(P趋势=0.0 3)以及雌二醇与睾酮的比值(P趋势=0.0 4)呈负相关。在绝经后的女性中，经常服用阿司匹林和其他止痛药的女性的雌激素水平可能低于不服用止痛药的女性，这可能有助于降低使用止痛药的女性患乳腺癌或卵巢癌的风险。癌症流行病学生物标记物；19(4)；1033-41。(C)2010年AACR。
Prior epidemiologic studies suggest that regular use of analgesics may decrease risk of breast and ovarian cancer. We explored possible hormone-mediated mechanisms for these associations by examining the relationship between use of aspirin, nonaspirin nonsteroidal anti-inflammatory drugs (NSAID), and acetaminophen and sex steroid hormone concentrations among 740 postmenopausal women in the Nurses' Health Study. All women reported their analgesic use in 1988 or 1990 and provided a blood sample in 1989 to 1990. We calculated adjusted geometric mean estrogen and androgen levels for each category of analgesic use and calculated the P value for trend with increasing frequency of use. There was no association between days of use per month of aspirin, nonaspirin NSAIDs, or acetaminophen in 1990 and hormone levels (all P-trend >= 0.09). However, we observed significant inverse trends between the estimated number of aspirin tablets per month in 1988 and concentrations of estrone (P-trend = 0.04) and estrone sulfate (P-trend = 0.03). In analyses of total (aspirin and nonaspirin) NSAID use in 1990, women who used NSAIDs at least 15 days per month had significantly lower levels of estradiol compared with women with no NSAID use (P-trend = 0.03). Frequency of use of all analgesics (aspirin, nonaspirin NSAIDs, and acetaminophen) in 1990 was inversely associated with concentrations of estradiol (P-trend = 0.001), free estradiol (P-trend = 0.01), estrone sulfate (P-trend = 0.03), and the ratio of estradiol to testosterone (P-trend = 0.04). Among postmenopausal women, regular users of aspirin and other analgesics may have lower estrogen levels than nonusers, which could contribute to a decreased risk of breast or ovarian cancer among analgesic users. Cancer Epidemiol Biomarkers Prev; 19(4); 1033-41. (C)2010 AACR.