Imipramine cardiotoxicity: an electrocardiographic and haemodynamic study in rabbits.
Imipramine cardiotoxicity: an electrocardiographic and haemodynamic study in rabbits.
复制标题
丙咪嗪心脏毒性：兔子心电图和血流动力学研究。
DOI：
10.1111/j.1600-0773.1980.tb02442.x
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
S. Schulze
中科院分区：
文献类型：
--
作者：
J. Müller;S. Schulze
本研究旨在探讨三环类抗抑郁药丙咪嗪的心脏毒性。本实验观察了家兔持续静脉滴注丙咪嗪时的心电图和血流动力学变化。采用基于Fick和Stewart汉密尔顿原理的放射性微球法测量血流量。结果发现，心率下降和心律变化总是在动脉血压和心肌收缩力下降之前，由dp/dtmax下降表示。结果的基础上，它的结论是，对心肌的直接抑制作用是心脏并发症的发展中的重要性，虽然这两个抑制心脏传导的影响，抗胆碱能作用，和肾上腺素能因子的影响也可能有助于。不能排除血浆丙咪嗪浓度变化与dp/dtmax和QRS波群变化之间呈正相关的可能性。
The purpose of the present study was to investigate the cardiotoxicity of the tricyclic antidepressant imipramine. The experiments were carried out in rabbits during continous intravenous infusion of imipramine, and electrocardiographic and haemodynamic changes were observed. The blood flows were measured using the radioactive microsphere method based upon the principles of Fick and Stewart Hamilton. It was found that the decrease in heart rate and the changes in heart rhythm were always preceded by a fall in arterial blood pressure and cardiac contractility, expressed by a fall in dp/dtmax. On the basis of the results it is concluded that a direct depressing action on the myocardium is of importance in the development of cardiac complications, although both a depressing influence on cardiac conduction, an anticholinergic effect, and an influence on adrenergic factors may also contribute. The possibility of positive correlations between the changes in plasma-imipramine concentration and the changes in the dp/dtmax and the QRS complex cannot be excluded.