Metformin: Effects on micro and macrovascular complications in type 2 diabetes
Metformin: Effects on micro and macrovascular complications in type 2 diabetes
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DOI：
10.1007/s10557-008-6092-0
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发表时间：
2008-06-01
影响因子：
3.4
通讯作者：
Bailey, Clifford J.
中科院分区：
文献类型：
--
作者：
Bailey, Clifford J.
前言抗高血压药二甲双胍广泛用于治疗2型糖尿病。来自英国前瞻性糖尿病研究的数据和大型医疗保健数据库的回顾性分析一致认为，二甲双胍可降低心肌梗死的发生率，并增加这些患者的生存率。这种明显的血管保护作用似乎是独立的血糖降低efficity.Effects二甲双胍Metaldehyde早已知道，以减少动物模型中动脉粥样硬化病变的发展，和临床研究表明，药物，以减少替代措施，如颈动脉内膜中层厚度。二甲双胍的抗动脉粥样硬化作用包括降低胰岛素抵抗、高胰岛素血症和肥胖。可能对血脂异常、促炎细胞因子和单核细胞粘附分子减少以及糖化状态改善有适度的有利作用，有利于大血管和微血管的内皮功能。此外，二甲双胍发挥抗血栓形成作用，有助于2型糖尿病患者动脉粥样硬化血栓形成风险的总体降低。
Introduction The antihyperglycaemic agent metformin is widely used in the treatment of type 2 diabetes. Data from the UK Prospective Diabetes Study and retrospective analyses of large healthcare databases concur that metformin reduces the incidence of myocardial infarction and increases survival in these patients. This apparently vasoprotective effect appears to be independent of the blood glucose-lowering efficacy.Effects of metformin Metformin has long been known to reduce the development of atherosclerotic lesions in animal models, and clinical studies have shown the drug to reduce surrogate measures such as carotid intima-media thickness. The anti-atherogenic effects of metformin include reductions in insulin resistance, hyperinsulinaemia and obesity. There may be modest favourable effects against dyslipidaemia, reductions in pro-inflammatory cytokines and monocyte adhesion molecules, and improved glycation status, benefiting endothelial function in the macro- and micro-vasculature. Additionally metformin exerts anti-thrombotic effects, contributing to overall reductions in athero-thrombotic risk in type 2 diabetic patients.