GLUCOSE INTOLERANCE DURING DIURETIC THERAPY Results of Trial by the European Working Party on Hypertension in the Elderly
GLUCOSE INTOLERANCE DURING DIURETIC THERAPY Results of Trial by the European Working Party on Hypertension in the Elderly
复制标题
利尿剂治疗期间的葡萄糖不耐受 欧洲老年人高血压工作组的试验结果
DOI：
10.1016/s0140-6736(78)90797-3
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. Tuomilehto
中科院分区：
文献类型：
--
作者：
A. Amery;C. Bulpitt;A. Schaepdryver;R. Fagard;J. Hellemans;A. Mutsers;P. Berthaux;M. Deruyttere;C. Dollery;F. Forette;P. Lund;J. Tuomilehto
在一项双盲、随机、对照试验中，119 名老年高血压患者接受了 1 年的随访，48 名患者接受了 2 年的随访，其中他们每天接受安慰剂或 25-50 毫克氢氯噻嗪和 50-100 毫克氨苯蝶啶。一半的积极治疗组还每天接受 250 毫克至 2 克甲基多巴。 2年后，积极治疗组的空腹血糖平均增加9·6 mg/dl，而安慰剂组平均下降3·1 mg（P<0·001）。口服 50 g 葡萄糖后 1 小时测定，活性组的血糖平均上升 26·6 mg/dl，服用安慰剂两年的患者血糖平均下降 5·3 mg/dl（P<0·05）。利尿剂的高血糖作用似乎与钾流失有关，因为在两组中，血清钾在两年内下降的患者中糖耐量受损最为明显。
119 elderly, hypertensive patients were followed-up for 1 year and 48 for 2 years in a double-blind, randomised, controlled trial in which they received either placebo or 25-50 mg hydrochlorothiazide and 50-100 mg of triamterene daily. Half of the active treatment group also received 250 mg to 2 g methyldopa daily. After 2 years the active treatment group had an average increase in fasting blood-sugar of 9·6 mg/dl compared with an average fall of 3·1 mg in the placebo group (P<0·001). Blood-glucose rose by an average of 26·6 mg/dl in the active group when determined 1 hour after 50 g oral glucose and decreased by an average of 5·3 mg/dl in patients who had been on placebo for two years (P<0·05). The hyperglycæmic effect of diuretics appeared to be related to potassium loss since, in both groups, impairment of glucose tolerance was most marked in those in whom the serum-potassium decreased over the 2 years.