Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation
Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation
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DOI：
10.1016/s0165-3806(03)00172-x
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发表时间：
2003-09-10
期刊：
影响因子：
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通讯作者：
Roberts, TPL
中科院分区：
文献类型：
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作者：
Gage, NM;Siegel, B;Roberts, TPL
电延迟（例如，PI和NI）和磁性（例如，M100）听觉诱发成分取决于年龄在典型的发展中的儿童，与较长的潜伏期为年轻（4-6岁）和较短的，成人一样的潜伏期为年龄较大（14-16岁）的儿童。诱发成分中与听觉相关的变化提供了听觉系统成熟的间接测量，并反映了发育过程中发生的变化。我们使用脑磁图（MEG）来研究孤独症（AD）儿童和对照组的左（LH）和右（RH）半球皮质听觉系统的成熟变化。我们记录了17名对照组和15名年龄范围为8-16岁的AD儿童的左右颞叶听觉诱发反应，并测量了M100潜伏期随年龄、受试者组和半球的变化。年龄和M100潜伏期的线性回归分析提供了按半球和受试者组的潜伏期变化率（ms/年）的估计值。对照组：该组的M100潜伏期范围为100.8至166.1 ms，在两个半球呈线性变化，以-4 ms/年（LH）和-4.5 ms/年（RH）的速率下降。AD：M100潜伏期范围为116.2至186.2 ins。LH或RH的回归线斜率与零无差异。LH的M100潜伏期呈随年龄变化的趋势，以-4.6 ms/年的速率下降。RH的M100潜伏期随着年龄的增长略有增加（以0.8 ms/年的速率）。结果提供了证据，AD儿童的听觉系统发育差异，这可能反映了AD的皮质成熟过程异常。(C)2003 Elsevier B. V.保留所有权利。
Latency of electric (e.g., PI and NI) and magnetic (e.g., M100) auditory evoked components depends on age in typically developing children, with longer latencies for younger (4-6 years) and shorter, adult-like latencies for older (14-16 years) children. Age-related changes in evoked components provide indirect measures of auditory system maturation and reflect changes that occur during development. We use magnetoencephalography (MEG) to investigate maturational changes in cortical auditory systems in left (LH) and right (RH) hemispheres in children with autism disorder (AD) and Controls. We recorded auditory evoked responses over left and right temporal lobes in 17 Control and 15 AD children in the age range 8-16 years and measured M100 latency as a function of age, subject group and hemisphere. Linear regression analyses of age and M100 latency provided an estimate of the rate of latency change (ms/year) by hemisphere and subject group. Controls: M100 latency for the group ranged from 100.8 to 166.1 ms and varied linearly in both hemispheres, decreasing at a rate of -4 ms/year (LH) and -4.5 ms/year (RH). AD: M100 latency ranged from 116.2 to 186.2 ins. Slopes of regression lines did not differ from zero in either LH or RH. M100 latency showed a tendency to vary with age in LH, decreasing at a rate of -4.6 ms/year. M100 latency in RH increased slightly (at a rate of 0.8 ms/year) with age. Results provide evidence for a differential auditory system development in AD children which may reflect abnormalities in cortical maturational processes in AD. (C) 2003 Elsevier B.V. All rights reserved.