Evaluation of terpene-based hydrophobic deep eutectic solvents as skin permeation enhancers
Evaluation of terpene-based hydrophobic deep eutectic solvents as skin permeation enhancers
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DOI：
10.35848/1347-4065/acb392
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发表时间：
2023-01-01
影响因子：
1.5
通讯作者：
Sakuragi, Mina
中科院分区：
文献类型：
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作者：
Araki, Yuta;Hamada, Yuma;Sakuragi, Mina
我们研究了羧酸-萜烯基低共熔溶剂（DES）是否可以用作皮肤渗透促进剂。我们进行了透皮实验，结果表明，具有较长烃链的DES可以增强亲水性荧光素钠和疏水性美洛昔康的皮肤渗透性。此外，所有DES都可以提高难溶性白藜芦醇的皮肤渗透性。随后，我们评估了应用DES后角质层的结构转变。结果表明，具有较长烃链的基于l-薄荷醇的DES比具有较短烃链的DES更破坏脂质层。基于百里酚的DES提取角质层中的脂质并渗透角质细胞。经皮水分损失测量表明，具有较长烃链的基于l-薄荷醇的DES和基于百里酚的DES损害皮肤，因为它们扰乱角质层脂质的内部。总之，我们得出结论，具有较长烃链的DES可通过减少皮肤刺激而用作各种药物的皮肤渗透促进剂。
We investigated whether carboxylic acid-terpene-based deep eutectic solvents (DESs) can be used as skin permeation enhancers. We performed transdermal experiments, and their results showed that DESs with longer hydrocarbon chains can enhance the skin permeability of hydrophilic fluorescein sodium and hydrophobic meloxicam. Additionally, all DESs could improve the skin permeability of poorly soluble resveratrol. Subsequently, we evaluated the stratum corneum's structural transition after applying DESs. The results showed that the l-menthol-based DESs with longer hydrocarbon chains disrupt lipid layers more than those with shorter hydrocarbon chains. Thymol-based DES extracted the lipids in the stratum corneum and permeated the corneocytes. Transepidermal water loss measurements showed that l-menthol-based DESs with longer hydrocarbon chains and thymol-based DESs damage skin as they disturb the inner parts of stratum corneum lipids. Overall, we concluded that DESs with longer hydrocarbon chains can be used as skin permeation enhancers for various drugs by reducing skin irritation.