Measures of adherence as predictors of early and total weight loss with intensive behavioral therapy for obesity combined with liraglutide 3.0 mg.
Measures of adherence as predictors of early and total weight loss with intensive behavioral therapy for obesity combined with liraglutide 3.0 mg.
复制标题
坚持测量作为早期和总体体重减轻的预测因素，针对肥胖的强化行为疗法联合利拉鲁肽 3.0mg。
DOI：
10.1016/j.brat.2020.103639
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发表时间：
2020
影响因子：
4.1
通讯作者：
Chao,ArianaM
中科院分区：
文献类型：
--
作者：
Tronieri,JenaS;Wadden,ThomasA;Walsh,Olivia;Berkowitz,RobertI;Alamuddin,Naji;Chao,ArianaM
肥胖症强化行为治疗（IBT）的个体减肥结果是可变的。本研究评估了访视出勤率、饮食自我监测、药物治疗和代餐依从性是否与IBT治疗后52周的体重减轻相关，并测试了这些关系是否独立于与早期体重减轻的相关性。这是一项随机试验的次要分析，其中150例受试者（76.1%为女性，55.8%为白色，BMI = 38.8 ± 4.8 kg/m2）接受IBT单药治疗、IBT+利拉鲁肽3.0 mg/d治疗或IBT-利拉鲁肽联合12周代餐饮食（多组分）治疗。在整个样本中，访视出勤率占52周体重减轻方差的14.8%，饮食自我监测增加了14.9%。只有自我监测与体重减轻独立相关。在100例接受利拉鲁肽治疗的受试者中，药物依从性占52周体重减轻方差的9.9%，自我监测和药物依从性均为独立相关因素。对于50名多组分参与者，代餐依从性并不能预测体重减轻。早期体重减轻与早期和随后的会议出席率和饮食自我监测有关。然而，自我监测和药物依从性仍然是重要的相关性，总体重减轻时，控制这个变量。有助于改善自我监测一致性和药物使用的策略可以改善IBT的体重减轻。
Individual weight loss outcomes with intensive behavioral therapy (IBT) for obesity are variable. The present study assessed whether visit attendance, dietary self-monitoring, medication, and meal-replacement adherence were associated with 52-week weight loss with IBT and tested whether these relationships were independent of associations with early weight loss. This was a secondary analysis of a randomized trial in which 150 participants (76.1% female, 55.8% white, BMI = 38.8 ± 4.8 kg/m2) received either IBT alone, IBT with liraglutide 3.0 mg/d, or IBT-liraglutide combined with a 12-week meal replacement diet (Multi-component). In the full sample, visit attendance accounted for 14.8% of the variance in 52-week weight loss and dietary self-monitoring added 14.9%. Only self-monitoring was independently associated with weight loss. In the 100 liraglutide-treated participants, medication adherence accounted for an additional 9.9% of the variance in 52-week weight loss, and both self-monitoring and medication adherence were independent correlates. For the 50 Multi-component participants, meal replacement adherence did not predict weight loss. Early weight loss was associated with higher early and subsequent session attendance and dietary self-monitoring. However, self-monitoring and medication adherence remained important correlates of total weight loss when controlling for this variable. Strategies that help improve self-monitoring consistency and medication usage could improve weight loss with IBT.