Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder
Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder
复制标题
未经药物治疗的重度抑郁症中缰核功能障碍与动机症状之间的关联
DOI：
10.1093/scan/nsx074
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发表时间：
2017-09-01
影响因子：
4.2
通讯作者：
Roiser, Jonathan P.
中科院分区：
文献类型：
--
作者：
Liu, Wen-Hua;Valton, Vincent;Roiser, Jonathan P.
外侧缰在奖赏和惩罚过程中起着核心作用，并被认为是抑郁症中快感缺乏的主要症状。这一假说主要是基于在抑郁症动物模型中对缰核高代谢的观察，但缰核的活性及其与抑郁症患者临床症状的关系仍不清楚。高分辨率功能性磁共振成像（fMRI）和计算建模被用来研究在概率强化学习任务中缰的活动，奖励和惩罚结果在21名未服药的重度抑郁症患者和17名健康参与者。高分辨率的解剖扫描也被收购，以评估组之间的差异，缰体积。健康个体在接受惩罚时显示出预期的左侧缰核激活，这种模式在预测错误处理的计算分析中得到了证实。在抑郁症患者中，有一个趋势，削弱左缰激活惩罚，而更大的左缰激活与更严重的抑郁症状和快感缺乏。我们还发现抑郁症患者的缰核体积更大，这与快感缺失症状有关。缰核功能障碍可能导致抑郁症患者对惩罚的异常反应，并出现快感缺乏等症状。
The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula hypermetabolism in animal models of depression, but the activity of habenula and its relationship with clinical symptoms in patients with depression remains unclear. High-resolution functional magnetic resonance imaging (fMRI) and computational modelling were used to investigate the activity of the habenula during a probabilistic reinforcement learning task with rewarding and punishing outcomes in 21 unmedicated patients with major depression and 17 healthy participants. High-resolution anatomical scans were also acquired to assess group differences in habenula volume. Healthy individuals displayed the expected activation in the left habenula during receipt of punishment and this pattern was confirmed in the computational analysis of prediction error processing. In depressed patients, there was a trend towards attenuated left habenula activation to punishment, while greater left habenula activation was associated with more severe depressive symptoms and anhedonia. We also identified greater habenula volume in patients with depression, which was associated with anhedonic symptoms. Habenula dysfunction may contribute to abnormal response to punishment in patients with depression, and symptoms such as anhedonia.