BINDING OF THE CHEMICAL CARCINOGEN, PARA-DIMETHYLAMINOAZOBENZENE, BY HUMAN-PLASMA LOW-DENSITY LIPOPROTEINS
BINDING OF THE CHEMICAL CARCINOGEN, PARA-DIMETHYLAMINOAZOBENZENE, BY HUMAN-PLASMA LOW-DENSITY LIPOPROTEINS
复制标题
DOI：
10.1016/0014-5793(79)80822-4
复制
发表时间：
1979-01-01
期刊：
影响因子：
3.5
通讯作者：
MORRISETT, JD
中科院分区：
文献类型：
--
作者：
CHEN, TC;BRADLEY, WA;MORRISETT, JD
人血浆脂蛋白是脂-蛋白复合物，在循环中运输水不溶性脂质，调节脂质合成和分解代谢[l-3]。多年来，血浆脂蛋白引起了对脂质转运和心血管疾病感兴趣的研究者的注意[4,5]。然而，除了参与脂质转运和代谢外，血浆脂蛋白的其他作用最近已被认识到，包括抑制淋巴细胞增殖和维持免疫稳态。血浆脂蛋白不仅运输脂质，还运输其他亲脂物质，如利血平[S]、胡萝卜素和番茄红素。a-生育酚和多酚[9]分别与人血浆低密度脂蛋白（LDL）和高密度脂蛋白（HDL）特异性相关。Benditt [IO]认为两种潜在的诱变剂，苯并- a]芘（BP）和甲酰基-三烯也由脂蛋白携带。据信，在观察到全身效应的化学致癌物或药物作用的情况下，血液是主要的运输机制
Human plasma lipoproteins are lipid-protein complexes that transport water-insoluble lipids in the circulation and regulate lipid synthesis and catabolism [l-3], For many years, the plasma lipoproteins have attracted the attention of investigators interested in lipid transport [4, 5] and cardiovascular disease, However, in addition to their involvement in lipid transport and metabolism, other roles for the plasma lipoproteins have been~ recognized recently9 inclu~ ng inhibition of lymphocyte proliferation [6] and maintenance of immunologic homeostasis [7]. Plasma lipoproteins transport not only lipids but other lipophilic materials such as the drug reserpine [S], &carotene and lycopene. a-Tocopherol and dolichol [9] are specifically associated with human plasma low density lipoproteins (LDL) and high density lipoproteins (HDL), respectively. Benditt [IO] has suggested that two potential mutagens, benzo~ a] pyrene (BP) and me~ ylchol~ threne~ are also carried by the lipoproteins. It is believed that the blood is the main transport mechanism in cases of chemical carcinogens or drug action where systemic effects are observed