Polydrug Use and HIV Risk Among People Who Inject Heroin in Tijuana, Mexico: A Latent Class Analysis.
Polydrug Use and HIV Risk Among People Who Inject Heroin in Tijuana, Mexico: A Latent Class Analysis.
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DOI：
10.3109/10826084.2015.1013132
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发表时间：
2015
影响因子：
2
通讯作者：
Roesch SC
中科院分区：
文献类型：
--
作者：
Meacham MC;Rudolph AE;Strathdee SA;Rusch ML;Brouwer KC;Patterson TL;Vera A;Rangel G;Roesch SC
虽然大多数人谁注射毒品（PWID）在蒂华纳，墨西哥，主要是注射海洛因，注射和非注射使用甲基苯丙胺和可卡因是常见的。我们研究了海洛因注射者使用多种药物的模式，以告知预防和治疗药物使用及其健康和社会后果。参与者为居住在天津的PWID，年龄≥ 18岁，在过去6个月内报告过海洛因注射，通过应答者驱动抽样招募（n=1025）。使用过去6个月多药和多途径用途：可卡因注射、可卡因吸烟或鼻吸、甲基苯丙胺注射、甲基苯丙胺吸烟或鼻吸的四个指标，进行潜在类别分析，以概率为基础将个体归入类别。潜在类别成员关系在多项逻辑回归中回归到协变量。测试1、2、3和4类的潜在类分析是拟合的，其中3类解决方案拟合最好。1类主要由海洛因使用定义（50.2%，n=515）; 2类由甲基苯丙胺和海洛因使用定义（43.7%，n=448），3类由甲基苯丙胺、可卡因和海洛因使用定义（6.0%，n=62）。双变量和多变量分析表明，一组甲基苯丙胺和可卡因使用者表现出较高的风险性行为和较低的海洛因注射频率，和一组甲基苯丙胺使用者谁是年轻的，更有可能是女性。根据甲基苯丙胺和可卡因的使用模式确定了海洛因PWID的离散亚型。这些研究结果确定了海洛因注射者的亚型，他们需要更有针对性的干预措施，以减少注射毒品的健康和社会危害。
Although most people who inject drugs (PWID) in Tijuana, Mexico, primarily inject heroin, injection and non-injection use of methamphetamine and cocaine is common. We examined patterns of polydrug use among heroin injectors to inform prevention and treatment of drug use and its health and social consequences. Participants were PWID residing in Tijuana aged ≥ 18 years who reported heroin injection in the past 6 months and were recruited through respondent driven sampling (n=1025). Latent class analysis was conducted to assign individuals to classes on a probabilistic basis, using four indicators of past 6 month polydrug and polyroute use: cocaine injecting, cocaine smoking or snorting, methamphetamine injecting, methamphetamine smoking or snorting. Latent class membership was regressed onto covariates in a multinomial logistic regression. Latent class analyses testing 1, 2, 3, and 4 classes were fit, with the 3-class solution fitting best. Class 1 was defined by predominantly heroin use (50.2%, n=515); class 2 by methamphetamine and heroin use (43.7%, n=448), and class 3 by methamphetamine, cocaine, and heroin use (6.0%, n=62). Bivariate and multivariate analyses indicated a group of methamphetamine and cocaine users that exhibited higher risk sexual practices and lower heroin injecting frequency, and a group of methamphetamine users who were younger and more likely to be female. Discrete subtypes of heroin PWID were identified based on methamphetamine and cocaine use patterns. These findings have identified subtypes of heroin injectors who require more tailored interventions to reduce the health and social harms of injecting drug use.