Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT
Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT
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DOI：
10.1088/0031-9155/41/11/017
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发表时间：
1996-11
影响因子：
3.5
通讯作者：
Yuuichiro Narita;Stefan Eberl;Hidehiro Iida;Brian Hutton;Michael Braun;Takashi Nakamura;George J. Bautovich
中科院分区：
文献类型：
--
作者：
Yuuichiro Narita;Stefan Eberl;Hidehiro Iida;Brian Hutton;Michael Braun;Takashi Nakamura;George J. Bautovich
散射校正是定量SPECT的先决条件，但可能会增加噪声。蒙特卡罗模拟（EGS 4）和物理体模测量被用来比较两种散射校正技术的准确性和噪声特性：三能窗（TEW）和透射相关卷积减法（TDCS）技术。研究了TDCS的两种散射函数：（i）最初提出的单指数函数和（ii）从我们的Monte Carlo模拟中证明是上级的指数加高斯散射函数。在圆柱体模和胸部体模中研究了信噪比（S/N）和准确性。将每种方法的结果与真实主要计数（模拟）或已知活性浓度（体模研究）进行比较。在所有情况下使用。优化的方法总体表现最好，所有模拟和物理体模研究的准确度均优于4%。在模拟胸部体模的心脏腔室中观察到TEW和的最大误差分别为-30%和-22%。TEW具有最差的S/N比的三种技术。两种TDCS方法的信噪比相似，仅略低于模拟真实原始数据的信噪比。因此，可以在信噪比相对较小的情况下获得准确的定量。
Scatter correction is a prerequisite for quantitative SPECT, but potentially increases noise. Monte Carlo simulations (EGS4) and physical phantom measurements were used to compare accuracy and noise properties of two scatter correction techniques: the triple-energy window (TEW), and the transmission dependent convolution subtraction (TDCS) techniques. Two scatter functions were investigated for TDCS: (i) the originally proposed mono-exponential function and (ii) an exponential plus Gaussian scatter function demonstrated to be superior from our Monte Carlo simulations. Signal to noise ratio (S/N) and accuracy were investigated in cylindrical phantoms and a chest phantom. Results from each method were compared to the true primary counts (simulations), or known activity concentrations (phantom studies). was used in all cases. The optimized method overall performed best, with an accuracy of better than 4% for all simulations and physical phantom studies. Maximum errors for TEW and of -30 and -22%, respectively, were observed in the heart chamber of the simulated chest phantom. TEW had the worst S/N ratio of the three techniques. The S/N ratios of the two TDCS methods were similar and only slightly lower than those of simulated true primary data. Thus, accurate quantitation can be obtained with , with a relatively small reduction in S/N ratio.