Reproductive factors, oral contraceptives and risk of malignant melanoma: Western Canada Melanoma Study.
Reproductive factors, oral contraceptives and risk of malignant melanoma: Western Canada Melanoma Study.
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DOI：
10.1038/bjc.1985.275
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发表时间：
1985-12
影响因子：
8.8
通讯作者：
Spinelli JJ
中科院分区：
文献类型：
--
作者：
Gallagher RP;Elwood JM;Hill GB;Coldman AJ;Threlfall WJ;Spinelli JJ
在加拿大西部四省进行了一项对361名女性黑色素瘤患者和年龄匹配对照的研究。对生殖因素的分析显示，活产数量与黑色素瘤风险之间存在显著的负相关。在调整宿主色素沉着因素、雀斑和教育状况后，浅表扩散性黑色素瘤的相关性仍然存在。双侧卵巢切除术和浅表扩散性黑色素瘤的风险之间也存在负相关。未发现黑色素瘤风险与初次生育年龄、初潮年龄和自然绝经年龄之间存在关联。未发现浅表扩散或结节性黑色素瘤的风险与口服避孕药或绝经期雌激素的使用之间存在关联。
A study of 361 female melanoma patients and age matched controls was conducted in the four western provinces of Canada. Analysis of reproductive factors showed a significant negative association between number of livebirths and risk of melanoma. The relationship persisted for superficial spreading melanomas after adjustment for host pigmentation factors, freckling, and educational status. An inverse association between bilateral oophorectomy and risk of superficial spreading melanoma was also seen. No association was found between risk of melanoma and age at first birth, age at menarche and age at natural menopause. No association was found between risk of superficial spreading or nodular melanoma and use of either oral contraceptives or menopausal oestrogens.