Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer Formation
Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer Formation
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DOI：
10.1074/jbc.c111.269050
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发表时间：
2011-10-14
影响因子：
4.8
通讯作者：
Liu, Xiaoqi
中科院分区：
文献类型：
--
作者：
Liu, X. Shawn;Song, Bing;Liu, Xiaoqi
背景：Pten的缺失被认为介导了大多数前列腺癌。结果：polo样激酶1赋予pten缺失的前列腺癌细胞致瘤能力。结论：polo样激酶1促进pten诱导的前列腺癌形成的丧失。意义：这些结果提供了解释癌细胞如何克服癌发生相关的细胞应激的机制。
Background: Loss of Pten is thought to mediate the majority of prostate cancers.Results: Polo-like kinase 1 confers the tumorigenic competence of Pten-deleted prostate cancer cells.Conclusion: Polo-like kinase 1 facilitates loss of Pten-induced prostate cancer formation.Significance: These results provide a mechanism explaining how cancer cells overcome oncogenesis-associated cellular stress.