Topographic Mapping-The Olfactory System
Topographic Mapping-The Olfactory System
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DOI：
10.1101/cshperspect.a001776
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发表时间：
2010-08-01
影响因子：
7.2
通讯作者：
Vosshall, Leslie B.
中科院分区：
文献类型：
--
作者：
Imai, Takeshi;Sakano, Hitoshi;Vosshall, Leslie B.
感觉系统必须在大脑中映射外部世界的准确表征。虽然触觉和视觉的物理感觉建立身体和视野的空间坐标的地形表示，嗅觉的化学感觉映射化学空间的不连续特征，包括极大量的可能的气味刺激。在哺乳动物和昆虫中，嗅觉回路是根据来自表达相同气味受体的感觉神经元的轴突的会聚而连接的。突触被组织成独特的球形神经柱-嗅觉小球-连接感觉输入与输出神经元和局部调节中间神经元。虽然哺乳动物和昆虫的嗅觉图中有很强的形式保守性，但它们使用不同的机制产生。嗅球为将不连续的化学空间映射到大脑上的问题提供了独特的解决方案。
Sensory systems must map accurate representations of the external world in the brain. Although the physical senses of touch and vision build topographic representations of the spatial coordinates of the body and the field of view, the chemical sense of olfaction maps discontinuous features of chemical space, comprising an extremely large number of possible odor stimuli. In both mammals and insects, olfactory circuits are wired according to the convergence of axons from sensory neurons expressing the same odorant receptor. Synapses are organized into distinctive spherical neuropils-the olfactory glomeruli-that connect sensory input with output neurons and local modulatory interneurons. Although there is a strong conservation of form in the olfactory maps of mammals and insects, they arise using divergent mechanisms. Olfactory glomeruli provide a unique solution to the problem of mapping discontinuous chemical space onto the brain.