Strategies for finding new pharmacological targets for neuropathic pain.
Strategies for finding new pharmacological targets for neuropathic pain.
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DOI：
10.1007/s11916-004-0050-8
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发表时间：
2004-06-01
影响因子：
3.7
通讯作者：
Devor, Marshal
中科院分区：
文献类型：
--
作者：
Devor, Marshal
神经性慢性疼痛是一个尚未满足的治疗挑战，可能需要开发新的药物实体。开发新药并在临床试验中进行测试所涉及的资源是如此之大，以至于很少有候选药物能够在实践中进行全面测试。一个糟糕的选择可能会产生重大影响。与此同时，近年来，研究界已经确定了大量潜在的镇痛药理学靶点，个别研究人员以越来越高的热情推广了自己喜欢的靶点。由于神经性疼痛动物模型的预测价值不确定，因此必须考虑合理的策略方法来选择最可能的候选靶点。
Chronic pain of neuropathic origin is an unmet therapeutic challenge that may require the development of novel drug entities. The resources involved in developing novel drugs and testing them in clinical trials are so large that few candidates can be fully tested in practice. A poor choice can have major repercussions. At the same time, the research community has identified large numbers of potential pharmacological targets for analgesia in recent years, with individual investigators promoting favorites with increasing zeal. Because of the uncertain predictive value of animal models of neuropathic pain, it is essential to consider rational strategic approaches to selecting the most likely candidate targets.