ADORA2A genotype modulates interoceptive and exteroceptive processing in a fronto-insular network
ADORA2A genotype modulates interoceptive and exteroceptive processing in a fronto-insular network
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DOI：
10.1016/j.euroneuro.2016.05.007
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发表时间：
2016-08-01
影响因子：
5.6
通讯作者：
Neufang, Susanne
中科院分区：
文献类型：
--
作者：
Geiger, Maximilian J.;Domschke, Katharina;Neufang, Susanne
显著性网络中的内感受和外感受信息加工促进了焦虑和焦虑障碍的发展。本研究研究了腺苷2a受体基因（ADORA2A） 1976T/C （rs5751876）变异是否参与了该网络的调节，该变异先前与焦虑障碍和焦虑相关表型以及一般注意力效率有关。详细地分析了65名健康参与者（女性=35）的fMRI记录，分析了ADORA2A基因型对大脑连通性的影响，这些连通性涉及(1)功能连通性静息状态fMRI的内感受加工，以及(2)基于任务的fMRI的动态因果建模的外感受加工。在一个亚样本中，通过心理跟踪任务进一步测量心脏内感受的准确性。研究发现，ADORA2A基因型在休息（内感受加工）和执行控制任务（外感受加工）时调节额岛网络。在两种模式中，ADORA2A TT风险基因型与脑岛和前额叶皮层之间的连通性增加有关。连通性的强度与内感受准确性相关。结果表明，脑额叶-脑岛连通性的改变是由腺苷能系统和内感觉准确性共同调节的。因此，具有ADORA2A基因型信息的额叶-岛叶连接概要可以作为针对外感受和内感受功能障碍的焦虑症个性化治疗方法的联合生物标志物。(C) 2016 Elsevier B.V.和ECNP。版权所有。
Facilitated processing of interoceptive and exteroceptive information in the salience network is suggested to promote the development of anxiety and anxiety disorders. Here, it was investigated whether the adenosine 2 A receptor gene (ADORA2A) 1976T/C (rs5751876) variant - previously associated with anxiety disorders and anxiety-related phenotypes as well as general attentional efficiency-was involved in the regulation of this network.In detail, fMRI recordings of 65 healthy participants (female=35) were analyzed regarding ADORA2A genotype effects on brain connectivity related to (1) interoceptive processing in terms of functional connectivity resting-state fMRI, and (2) exteroceptive processing using dynamic causal modeling in task-based fMRI. In a subsample, cardiac interoceptive accuracy was furthermore measured via the Mental Tracking Task.ADORA2A genotype was found to modulate a fronto-insular network at rest (interoceptive processing) and while performing an executive control task (exteroceptive processing). Across both modalities, the ADORA2A TT risk genotype was associated with increased connectivity between the insula and the prefrontal cortex. The strength in connectivity correlated with interoceptive accuracy.It is concluded that alterations in fronto-insular connectivity are modulated by both the adenosinergic system and interoceptive accuracy. Thus, fronto-insular connectivity in synopsis with ADORA2A genotypic information could serve as combined biomarkers for personalized treatment approaches in anxiety disorders targeting exteroceptive and interoceptive dysfunction. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.