Food-stimulated gastric acid secretion inhibited by hormones and drugs. The role of vagal innervation.
Food-stimulated gastric acid secretion inhibited by hormones and drugs. The role of vagal innervation.
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发表时间：
1981
影响因子：
1.9
通讯作者：
I. Guldvog;M. Getz
中科院分区：
文献类型：
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作者：
I. Guldvog;M. Getz
7只具有迷走神经支配的Amdrup育儿袋（AP）和去神经支配的Heidenhain育儿袋（HP）的双育儿袋犬，可以在同一动物中同时比较有神经支配和去神经支配的粘膜的胃分泌物。刺激是通过食物来完成的——肝脏、心脏和骨粉的混合物，每公斤10g。西咪替丁，25、50、100、200和400毫克；阿托品，0.031,0.125,0.5和1.0 mg；生长抑素，0.5、1.0、2.0微克/kg/h；分泌素2 U/kg/h，餐后60 min给予，每天1次。所有化合物和所有剂量均显示出对两袋胃酸分泌的抑制作用，所有化合物的小剂量对失神经粘膜的抑制作用更为明显。此外，失神经粘膜的效果持续时间更长。在服用生长抑素后，观察到明显的反弹效应。抑制后，西咪替丁和阿托品的输出量也明显高于对照组，但仅在神经支配的粘膜。
Seven double-pouch dogs with one vagally innervated Amdrup pouch (AP) and one denervated Heidenhain pouch (HP) made possible comparison of gastric secretion from innervated and denervated mucosa at the same time in the same animal. Stimulation was done by food--a mixture of liver, heart, and bonemeal, 10g/kg. Cimetidine, 25, 50, 100, 200, and 400 mg; atropine, 0.031, 0.125, 0.5 and 1.0 mg; somatostatin, 0.5, 1.0, and 2.0 micrograms/kg/h; and secretin, 2 U/kg/h, were given 60 min after the meal, one single dose on each day. All compounds and all doses showed inhibition of gastric acid secretion in both pouches, significantly more pronounced in denervated mucosa for smaller doses of all compounds. In addition, the effect lasted longer in denervated mucosa. After somatostatin a pronounced rebound effect was seen. Cimetidine and atropine also showed significantly higher output than controls after the inhibition, but only in innervated mucosa.