[An epizootic Staphylococcus infection in a nude mouse colony].
[An epizootic Staphylococcus infection in a nude mouse colony].
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[裸鼠群体中流行的葡萄球菌感染]。
DOI：
10.1538/expanim1978.37.1_31
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
S. Kimura
中科院分区：
文献类型：
--
作者：
R. Sano;S. Yamamoto;H. Kamimura;M. Kimura;K. Ueda;A. Shimizu;J. Kawano;S. Kimura
在BALB/c背景的一个小规模裸鼠繁殖群中发生了一次葡萄球菌感染引起的动物流行病。脓肿的发病率是散发性的，大多数年龄超过3个月的裸鼠（nu/nu）受到影响。从殖民地中几乎所有nu/nu和杂合（nu/+）小鼠的面部、口腔和粪便中分离出金黄色葡萄球菌。经过一段时间的延长，直到10到14个月的年龄，几乎所有的S。携带金黄色葡萄球菌的nu/nu小鼠产生流产并最终死亡。宿主的无免疫力似乎是脓肿形成的先决条件，因为nu/+小鼠免于病变。移植免疫活性的脾细胞也能治愈受影响裸鼠的肿瘤。
An epizootic of Staphylococcus infection causing abscesses was encountered in a small-scale breeding colony of nude mice of BALB/c background. The incidence of abscess was sporadic and mostly nude (nu/nu) mice aged over 3 months were affected. Staphylococcus aureus was isolated from the face, oral cavity, and feces of almost all nu/nu and heterozygous (nu/+) mice in the colony. After a prolonged time period, up to 10 to 14 months of age, almost all the S. aureus-carrying nu/nu mice produced abscesses and eventually died. Athymicity of the host seemed to be a prerequisite for the abscess formation since nu/+ mice were spared from the lesions. Also, transfer of immunocompetent spleen cells cured the abscesses of the affected nude mice.