LOCALIZATION OF VISUAL-STIMULI AFTER STRIATE CORTEX DAMAGE IN MONKEYS - PARALLELS WITH HUMAN BLINDSIGHT
LOCALIZATION OF VISUAL-STIMULI AFTER STRIATE CORTEX DAMAGE IN MONKEYS - PARALLELS WITH HUMAN BLINDSIGHT
复制标题
DOI：
10.1073/pnas.92.18.8215
复制
发表时间：
1995-08-29
影响因子：
11.1
通讯作者：
GROSS, CG
中科院分区：
文献类型：
--
作者：
MOORE, T;RODMAN, HR;GROSS, CG
盲视是一种现象，在这种现象中，患有纹状皮层损伤的人类患者在由此产生的视野缺陷中否认任何视觉感觉，但是当被说服猜测时，仍然可以检测和定位刺激。虽然有条纹病变的猴子也显示出一些残余视力，但目前还不清楚猴子的残余能力在多大程度上与人类的盲视现象相似。为了阐明这个问题，我们训练了两只单侧纹状体皮质损伤的猴子在两种条件下对两个半视野中的视觉目标进行扫视运动。在类似于临床视野检查的条件下，它们未能对侧半视野中的目标发起扫视，因此表现为“盲”。"只有在目标出现的同时关闭注视点的情况下--给动物发出信号，让它们在适当的时间做出反应--猴子才能将目标定位在纹状体损伤的对侧。这些结果表明，在何种条件下，剩余视力是可证明的是相似的猴子与纹状皮质损伤和人类失明。
Blindsight is a phenomenon in which human patients with damage to striate cortex deny any visual sensation in the resultant visual field defect but can nonetheless detect and localize stimuli when persuaded to guess. Although monkeys with striate lesions have also been shown to exhibit some residual vision, it is not yet clear to what extent the residual capacities in monkeys parallel the phenomenon of human blindsight. To clarify this issue, we trained two monkeys with unilateral lesions of striate cortex to make saccadic eye movements to visual targets in both hemifields under two conditions, In the condition analogous to clinical perimetry, they failed to initiate saccades to targets presented in the contralateral hemifield and thus appeared ''blind.'' Only in the condition where the fixation point was turned off simultaneously with the onset of the target-signaling the animal to respond at the appropriate time-were monkeys able to localize targets contralateral to the striate lesion. These results indicate that the conditions under which residual vision is demonstrable are similar for monkeys with striate cortex damage and humans with blindsight.