Inter-comparison of Dose Distributions Calculated by FLUKA, GEANT4, MCNP, and PHITS for Proton Therapy
Inter-comparison of Dose Distributions Calculated by FLUKA, GEANT4, MCNP, and PHITS for Proton Therapy
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FLUKA、GEANT4、MCNP 和 PHITS 计算的质子治疗剂量分布的相互比较
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
R. Sheu
中科院分区：
文献类型：
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作者：
Zi;P. Tsai;Shao;Yen;Chin;Tatsuhiko Sato;R. Sheu
利用FLUKA、GEANT4、MCNP和PHITS计算了质子笔形束扫描的剂量分布，以探讨其在质子放射治疗中的适用性。第一个研究的情况下，综合深度剂量曲线（IDDC），分别从100和226 MeV的质子笔束撞击水幻影。只要每个代码采用75 eV的电离势的水，计算的IDDC彼此同意。第二种情况考虑了与第一种情况类似的条件，但质子能量呈高斯分布。与测量结果的比较表明，码间差异不仅是由于阻止本领的不同，而且可能是由于核物理模型的不同。讨论了物理参数设置对计算时间的影响。在第三种情况下，通过根据治疗计划提供均匀的体积剂量分布来确认每个代码对笔形射束扫描的适用性，结果显示每个代码、治疗计划和测量之间基本一致，但在半影区发现了一些偏差。本研究表明，选定的代码都能够进行剂量计算的治疗扫描质子束与适当的物理设置。
The dose distributions from proton pencil beam scanning were calculated by FLUKA, GEANT4, MCNP, and PHITS, in order to investigate their applicability in proton radiotherapy. The first studied case was the integrated depth dose curves (IDDCs), respectively from a 100 and a 226-MeV proton pencil beam impinging a water phantom. The calculated IDDCs agree with each other as long as each code employs 75 eV for the ionization potential of water. The second case considered a similar condition of the first case but with proton energies in a Gaussian distribution. The comparison to the measurement indicates the inter-code differences might not only due to different stopping power but also the nuclear physics models. How the physics parameter setting affect the computation time was also discussed. In the third case, the applicability of each code for pencil beam scanning was confirmed by delivering a uniform volumetric dose distribution based on the treatment plan, and the results showed general agreement between each codes, the treatment plan, and the measurement, except that some deviations were found in the penumbra region. This study has demonstrated that the selected codes are all capable of performing dose calculations for therapeutic scanning proton beams with proper physics settings.
影响因子：
3.8
作者：
Sawakuchi, Gabriel O.;Mirkovic, Dragan;Titt, Uwe
通讯作者：
Titt, Uwe