Symptom Clusters and Influencing Factors in Family Caregivers of Individuals With Cancer.
Symptom Clusters and Influencing Factors in Family Caregivers of Individuals With Cancer.
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癌症患者家庭照顾者的症状群及影响因素
DOI：
10.1097/ncc.0000000000000877
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发表时间：
2021-11-01
期刊：
影响因子：
2.6
通讯作者：
Ross A
中科院分区：
文献类型：
--
作者：
Lee LJ;Wehrlen L;Wallen GR;Ding Y;Ross A
症状群是一组2个或多个症状，这些症状一起出现并且彼此相关。虽然癌症患者的家庭照顾者会经历多种并发症状，但大多数症状研究都集中在评估和管理个体的孤立症状。本研究旨在探讨癌症照顾者的症状群，并探讨影响症状群的因素。聚类分析使用的横断面调查数据，从129个家庭照顾者的个人接受癌症治疗，在美国国立卫生研究院临床中心。使用PROMIS（患者报告结局测量信息系统）测量照顾者的5种常见症状（疲劳、睡眠障碍、抑郁、焦虑、认知受损）来识别症状群。确定了两个症状集群组：低症状负担（n = 106，82.2%）和高症状负担（n = 23，17.8%）。报告更高水平的生活负担（对健康子量表的影响）（β = 1.31，P = 0.005）和孤独（β = 0.18，P = 0.024）的个体更有可能属于高症状负担组。这项研究提供的证据表明，癌症照顾者的5个关键症状似乎可以分为2组，即症状负担低的组和症状负担高的组。照顾负担（影响健康）和孤独感是区分症状群成员的重要因素。识别症状群可能会导致更好的预防和治疗策略，针对癌症照顾者的症状。确定使一个群体处于症状负担高风险的因素，可用于指导个性化和量身定制的干预措施。
A symptom cluster is a group of 2 or more symptoms that occur together and are related to each other. Although family caregivers of individuals with cancer experience multiple concurrent symptoms, the majority of symptom research has focused on assessing and managing individual, isolated symptoms. The study purpose was to investigate symptom clusters in cancer caregivers and to explore factors that influence symptom clusters. Cluster analysis was performed using cross-sectional survey data from 129 family caregivers of individuals receiving cancer treatment at the National Institutes of Health Clinical Center. PROMIS (Patient-Reported Outcomes Measurement Information System) measures of 5 common symptoms in caregivers (fatigue, sleep disturbance, depression, anxiety, impaired cognition) were used to identify symptom clusters. Two symptom cluster groups were identified: low symptom burden (n = 106, 82.2%) and high symptom burden (n = 23, 17.8%). Individuals who reported higher levels of caregiving burden (impact on health subscale) (β = 1.31, P = .005) and loneliness (β = 0.18, P = .024) were significantly more likely to be in the high symptom burden group. This study provides evidence that 5 key symptoms among cancer caregivers appear to cluster into 2 groups, those with low symptom burden and those with high symptom burden. Caregiving burden (impact of health) and loneliness were significant factors differentiating symptom cluster membership. Identifying symptom clusters may lead to better prevention and treatment strategies that target symptoms in cancer caregivers. Identifying factors that place a group at high risk of symptom burden can be used to guide individualized and tailored interventions.