Cold Plasma Irradiation Attenuates Atopic Dermatitis via Enhancing HIF-1α-Induced MANF Transcription Expression.
Cold Plasma Irradiation Attenuates Atopic Dermatitis via Enhancing HIF-1α-Induced MANF Transcription Expression.
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冷等离子体照射通过增强 HIF-1α 诱导的 MANF 转录表达来减轻特应性皮炎
DOI：
10.3389/fimmu.2022.941219
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
冷气血浆在临床上被广泛应用，尤其是皮肤疾病血浆能够降低皮肤细胞的凋亡，挽救皮肤感染，ER应激和由二硝氟苯模拟是由冷大气血浆诱导的MANF表达介导的。表达。通过HIF-1α表达MANF表达的冷大气血浆的调节机制，这表明冷大气血浆的潜在医学应用用于特应性皮炎治疗。
Cold atmospheric plasma has been widely applied in medical treatment clinically, especially skin diseases. However, the mechanism of cold atmospheric plasma on the treatment of skin diseases is still undefined. In this study, dinitrofluorobenzene-induced atopic dermatitis mice model was constructed. Cold atmospheric plasma was able to decrease skin cells apoptosis, relieve skin inflammation, ER stress and oxidative stress caused by dinitrofluorobenzene stimulation, which was mediated by cold atmospheric plasma-induced MANF expression. In terms of mechanism, hypoxia-inducible factor-1α expression was increased intracellularly after cold atmospheric plasma treatment, which further bound to the promoter region of manf gene and enhanced MANF transcriptional expression. This study reveals that cold atmospheric plasma has a positive effect on atopic dermatitis treatment, also demonstrates the regulatory mechanism of cold atmospheric plasma on MANF expression via HIF-1α, which indicates the potential medical application of cold atmospheric plasma for atopic dermatitis treatment.
影响因子：
4.6
作者：
Shi YL;Gu J;Park JJ;Xu YP;Yu FS;Zhou L;Mi QS
通讯作者：
Mi QS