SPASM IN ECTATIC CORONARY-ARTERIES
SPASM IN ECTATIC CORONARY-ARTERIES
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DOI：
10.1016/s0025-6196(12)64787-9
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发表时间：
1985-01-01
影响因子：
8.9
通讯作者：
VLIETSTRA, RE
中科院分区：
文献类型：
--
作者：
BOVE, AA;VLIETSTRA, RE
冠状动脉扩张的患者通常有受影响的动脉闭塞。由于扩张动脉被认为具有中膜损伤，因此通常认为它们几乎没有收缩能力;因此，痉挛不被认为是闭塞过程中的一个因素。在两个弥漫性冠状动脉扩张、无明显狭窄和心绞痛的患者中，我们发现扩张的动脉确实对麦角新碱有增强的血管收缩反应。这一发现表明，一些扩张的动脉有足够数量的平滑肌引起冠状动脉痉挛，并可能通过引起复发性动脉痉挛而产生冠心病症状。
Patients with ectatic coronary arteries often have occlusion of the affected arteries. Because ectatic arteries are considered to have medial damage, they are normally assumed to have little capacity to constrict; therefore, spasm has not been considered a factor in the occlusive process. In two patients who had diffuse coronary ectasia, no appreciable stenosis, and angina pectoris, we found that the ectatic arteries indeed had an augmented vasoconstrictor response to ergonovine. This finding indicates that some ectatic arteries have a sufficient amount of smooth muscle to cause coronary spasm and may produce symptoms of coronary disease by causing recurrent arterial spasm.