Decreased production of mast cells in S1/S1d anemic mice.
Decreased production of mast cells in S1/S1d anemic mice.
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S1/S1d 贫血小鼠肥大细胞的产生减少。
DOI：
10.1182/blood.v53.3.492.492
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发表时间：
1979
期刊：
影响因子：
20.3
通讯作者：
S. Go
中科院分区：
文献类型：
--
作者：
Y. Kitamura;S. Go
在 Si ISid 基因型的遗传性贫血小鼠中评估了组织肥大细胞的产生。在成年Si ISid小鼠的皮肤中，每厘米肥大细胞的数量少于在同系+ I + 小鼠中观察到的数量的1%。正如成年 WI WV 小鼠的报道。 SiIS1d 和 WIWV 小鼠的其他组织中几乎未检测到任何肥大细胞。由于 51151d 小鼠的骨髓细胞移植增加了皮肤中肥大细胞的数量。胃。和 WI WV 小鼠的肠系膜。 S1IS1d 小鼠的骨髓似乎含有肥大细胞的前体。这些前体细胞可能到达外周组织。观察结果表明，移植到受体的 W/WV 小鼠皮肤中肥大细胞的数量增加。 51151d小鼠中肥大细胞的缺乏似乎是由于局部诱导肥大细胞分化的组织缺陷所致。正如观察结果所示，来自+I+供体的骨髓移植不会增加皮肤中肥大细胞的数量。胃。 51151d 小鼠的肠系膜和肠系膜，并观察到移植到 + I + 受体的 Si ,51d 小鼠的皮肤中没有肥大细胞发育。
Production of tissue mast cells was evaluated in genetically anemic mice of Si ISid genotype. In the skin of adult Si ISid mice the numbers of mast cells per centimeter were less than 1 % of the numbers observed in congenic + I + mice. as reported for adult WI WV mice. Any mast cells were scarcely detected in other tissues in both SiIS1d and WIWV mice. Since bone marrow cell transplantation from 51151d mice increases the numbers of mast cells in the skin. stomach. and mesentery of WI WV mice. the bone marrow of S1IS1d mice would seem to contain precursors of mast cells. These precursor cells may arrive at peripheral tissues. as is suggested by the observation that the numbers of mast cells increase in the skin of W/WV mice grafted to recipients. The lack of mast cells in the 51151d mice seems to be due to a tissue defect that locally induces the differentiation of mast cells. as isindicated by the observation that bone marrow transplantation from + I + donors does not increase the numbers of mast cells in the skin. stomach. and mesentery of 51151d mice and the observation that mast cells do not develop in skin of Si ,51d mice grafted to + I + recipients.